staflu
Generic Name
Flucloxacillin 250 mg capsule
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| staflu 250 mg capsule | ৳ 5.79 | ৳ 23.16 |
Description
Overview of the medicine
Staflu 250 mg Capsule contains Flucloxacillin, a penicillinase-resistant penicillin antibiotic used to treat various bacterial infections, especially those caused by penicillinase-producing staphylococci.
Uses & Indications
Dosage
Adults
Usual dose is 250-500 mg every 6 hours, preferably 30-60 minutes before meals. For severe infections, the dose may be increased.
Elderly
No specific dose reduction is usually required unless there is significant renal impairment. Use with caution and monitor renal function.
Renal_impairment
In severe renal impairment (creatinine clearance <10 mL/min), the dose should be reduced or the dosing interval prolonged (e.g., 250 mg every 8 or 12 hours) to avoid accumulation.
How to Take
Take orally, preferably 30-60 minutes before meals, with a glass of water. Do not chew or crush the capsule.
Mechanism of Action
Flucloxacillin acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan polymers, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Primarily excreted unchanged in the urine, with some excretion via bile.
Half life
Approximately 0.5-1.5 hours in individuals with normal renal function.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken on an empty stomach. Peak plasma concentrations typically occur 1-2 hours after oral administration.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Flucloxacillin, other penicillins, or any component of the formulation
- History of cholestatic jaundice/hepatic dysfunction associated with Flucloxacillin
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Close monitoring of INR and dose adjustment of warfarin may be necessary.
Probenecid
Probenecid delays the renal excretion of flucloxacillin, leading to increased and prolonged plasma concentrations.
Methotrexate
Flucloxacillin may reduce the renal excretion of methotrexate, potentially increasing its toxicity.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and electrolyte imbalance. Management is supportive and symptomatic; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use during pregnancy only if clearly needed. Flucloxacillin is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Flucloxacillin, other penicillins, or any component of the formulation
- History of cholestatic jaundice/hepatic dysfunction associated with Flucloxacillin
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin. Close monitoring of INR and dose adjustment of warfarin may be necessary.
Probenecid
Probenecid delays the renal excretion of flucloxacillin, leading to increased and prolonged plasma concentrations.
Methotrexate
Flucloxacillin may reduce the renal excretion of methotrexate, potentially increasing its toxicity.
Storage
Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and electrolyte imbalance. Management is supportive and symptomatic; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use during pregnancy only if clearly needed. Flucloxacillin is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Flucloxacillin has undergone extensive clinical trials demonstrating its efficacy and safety in treating susceptible bacterial infections since its introduction.
Lab Monitoring
- Liver function tests (ALT, AST, alkaline phosphatase, bilirubin), especially during prolonged therapy or in patients with pre-existing hepatic impairment.
- Renal function tests (serum creatinine) in patients with renal impairment.
- Complete blood count (CBC) in prolonged treatment.
Doctor Notes
- Emphasize completing the full course to prevent resistance.
- Advise patients to report any signs of allergic reactions or jaundice immediately.
- Consider liver function monitoring for extended therapy or at-risk patients.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve.
- Take this medicine on an empty stomach for better absorption.
- Inform your doctor about any history of allergy to penicillin or other antibiotics.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Flucloxacillin is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid alcohol during the course of treatment, as it may exacerbate gastrointestinal side effects.
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