Staflu
Generic Name
Flucloxacillin 500 mg capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| staflu 500 mg capsule | ৳ 10.57 | ৳ 42.28 |
Description
Overview of the medicine
Flucloxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat bacterial infections caused by susceptible Gram-positive bacteria.
Uses & Indications
Dosage
Adults
250-500 mg every 6 hours, usually for 5-7 days or longer depending on infection severity.
Elderly
Same as adults, but dose adjustment may be required in severe renal impairment.
Renal_impairment
Dose reduction needed for severe renal impairment (e.g., CrCl < 10 mL/min).
How to Take
Take orally, preferably on an empty stomach (at least 30 minutes before food or 2 hours after food) to ensure optimal absorption.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Pharmacokinetics
Onset
Rapid (within 30-60 minutes).
Excretion
Primarily excreted unchanged in urine by renal tubular secretion and glomerular filtration.
Half life
Approximately 0.5-1 hour.
Absorption
Well absorbed orally, especially on an empty stomach. Peak plasma levels usually occur 1-2 hours after oral administration.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to penicillin antibiotics or any component of the formulation.
- History of flucloxacillin-associated jaundice/hepatic dysfunction.
Drug Interactions
Warfarin
May potentiate anticoagulant effect, requiring closer INR monitoring.
Probenecid
Increases and prolongs flucloxacillin blood levels.
Methotrexate
Increased methotrexate toxicity due to reduced renal excretion.
Oral Contraceptives
May reduce efficacy of oral contraceptives (advise additional contraception).
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptomatic and supportive treatment. No specific antidote. Hemodialysis is not effective.
Pregnancy & Lactation
Use with caution during pregnancy; generally considered safe but consult a doctor. Excreted in breast milk, monitor infant for potential adverse effects (e.g., diarrhea, rash).
Side Effects
Contraindications
- Hypersensitivity to penicillin antibiotics or any component of the formulation.
- History of flucloxacillin-associated jaundice/hepatic dysfunction.
Drug Interactions
Warfarin
May potentiate anticoagulant effect, requiring closer INR monitoring.
Probenecid
Increases and prolongs flucloxacillin blood levels.
Methotrexate
Increased methotrexate toxicity due to reduced renal excretion.
Oral Contraceptives
May reduce efficacy of oral contraceptives (advise additional contraception).
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptomatic and supportive treatment. No specific antidote. Hemodialysis is not effective.
Pregnancy & Lactation
Use with caution during pregnancy; generally considered safe but consult a doctor. Excreted in breast milk, monitor infant for potential adverse effects (e.g., diarrhea, rash).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied since its introduction; numerous studies supporting efficacy and safety.
Lab Monitoring
- Liver function tests (LFTs) if treatment is prolonged or in patients with pre-existing hepatic impairment.
- Renal function tests for patients with renal impairment.
- Complete blood count (CBC) if treatment is prolonged.
Doctor Notes
- Emphasize taking on an empty stomach for optimal absorption.
- Monitor liver function in patients with pre-existing hepatic disease or on prolonged therapy.
- Advise patients to complete the full course to prevent resistance.
Patient Guidelines
- Complete the full course of antibiotics, even if symptoms improve.
- Take on an empty stomach for best absorption.
- Report any signs of allergic reaction or jaundice immediately.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
Generally safe, but if dizziness or other CNS effects occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment, as it may exacerbate gastrointestinal side effects.
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