Stebet-CL
Generic Name
Betamethasone Dipropionate + Clotrimazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| stebet cl 005 1 cream | ৳ 35.00 | N/A |
Description
Overview of the medicine
Stebet-CL is a topical combination medication containing a potent corticosteroid (Betamethasone Dipropionate) and an antifungal agent (Clotrimazole). It is used to treat various inflammatory dermatoses where secondary fungal infection is present or suspected.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area twice daily, morning and evening, for up to two weeks. Do not use for more than 4 weeks.
Elderly
Similar to adult dosage, use with caution due to thinner skin.
Renal_impairment
No specific dosage adjustment required for topical use.
How to Take
For external use only. Apply a thin film to the affected skin areas and gently rub in. Wash hands before and after application. Avoid contact with eyes, mouth, and other mucous membranes.
Mechanism of Action
Betamethasone acts by inducing phospholipase A2 inhibitory proteins, reducing the release of arachidonic acid, and thus suppressing inflammation. Clotrimazole inhibits the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to increased cell permeability and death.
Pharmacokinetics
Onset
Hours to days for symptomatic relief.
Excretion
Mainly renal and biliary for absorbed components.
Half life
Not well established for topical use; systemic half-life of Betamethasone is ~5 hours, Clotrimazole ~2 hours.
Absorption
Minimal systemic absorption through intact skin. Absorption increases with inflammation or occlusion.
Metabolism
Primarily hepatic for absorbed components.
Side Effects
Contraindications
- Hypersensitivity to Betamethasone, Clotrimazole, or any component of the formulation
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin
- Acne rosacea, perioral dermatitis
- Vaccination lesions
Drug Interactions
None significant for topical application under normal conditions.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged excessive use may lead to systemic corticosteroid effects (e.g., Cushing's syndrome) or local adverse effects (skin atrophy). Symptomatic and supportive treatment.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor. Prolonged use or application to large areas should be avoided.
Side Effects
Contraindications
- Hypersensitivity to Betamethasone, Clotrimazole, or any component of the formulation
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin
- Acne rosacea, perioral dermatitis
- Vaccination lesions
Drug Interactions
None significant for topical application under normal conditions.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged excessive use may lead to systemic corticosteroid effects (e.g., Cushing's syndrome) or local adverse effects (skin atrophy). Symptomatic and supportive treatment.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor. Prolonged use or application to large areas should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Studies have shown efficacy in reducing inflammation and fungal burden in mixed dermatoses. Long-term safety data for specific combination formulations are generally limited to the individual components.
Lab Monitoring
- No routine lab monitoring required for topical use. Monitor for signs of systemic corticosteroid absorption with prolonged or extensive use.
Doctor Notes
- Advise patients to use sparingly and for the shortest duration necessary.
- Warn against using on the face or in skin folds unnecessarily to avoid local side effects.
- Educate on the signs of fungal clearance vs. steroid withdrawal effects.
Patient Guidelines
- Use exactly as directed by your doctor.
- Do not apply to open wounds or broken skin.
- Avoid using on the face, groin, or underarms unless directed by a doctor.
- Do not cover the treated area with bandages or other dressings unless advised by a doctor.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
Driving Precautions
Stebet-CL is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene of the affected area.
- Wear loose-fitting clothing to avoid irritation.
- Avoid scratching the affected area.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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