Steclo
Generic Name
Clobetasol Propionate 0.05% Cream
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| steclo 005 cream | ৳ 58.00 | N/A |
Description
Overview of the medicine
Steclo-005-cream is a potent topical corticosteroid containing Clobetasol Propionate 0.05% w/w. It is used for the short-term treatment of inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin areas once or twice daily for a maximum of 2 consecutive weeks. Do not exceed 50 g per week.
Elderly
Use with caution due to thinner skin and increased risk of systemic absorption. Lower frequency or shorter duration may be considered.
Renal_impairment
No specific dose adjustment required, but caution is advised due to potential for systemic absorption.
How to Take
For external use only. Apply sparingly to the affected area and rub in gently. Wash hands after application. Avoid contact with eyes and mucous membranes. Do not use on face, groin, or axillae unless directed by a physician. Do not use occlusive dressings unless advised.
Mechanism of Action
Clobetasol Propionate acts by inducing phospholipase A2 inhibitory proteins, called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Onset
Clinical effects usually observed within a few days of initiation.
Excretion
Excreted via the kidneys and bile.
Half life
Systemically absorbed clobetasol propionate has a plasma half-life of approximately 4-6 hours.
Absorption
Systemic absorption of topical corticosteroids can occur, especially with prolonged use, application to large surface areas, or occlusive dressings. Absorption is increased in children and patients with impaired skin barrier function.
Metabolism
Metabolized primarily in the liver.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or other corticosteroids
- Untreated cutaneous infections
- Rosacea
- Acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
- Children under 12 years (generally)
Drug Interactions
Immunosuppressants
May increase immunosuppression if significant systemic absorption occurs.
Other topical corticosteroids
Increased risk of systemic effects and local side effects.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely. In case of chronic overdose or misuse, symptoms of hypercorticism (e.g., Cushing's syndrome) may appear. Treatment is symptomatic and supportive; gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy: Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: It is unknown whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate or other corticosteroids
- Untreated cutaneous infections
- Rosacea
- Acne vulgaris
- Perioral dermatitis
- Pruritus without inflammation
- Children under 12 years (generally)
Drug Interactions
Immunosuppressants
May increase immunosuppression if significant systemic absorption occurs.
Other topical corticosteroids
Increased risk of systemic effects and local side effects.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely. In case of chronic overdose or misuse, symptoms of hypercorticism (e.g., Cushing's syndrome) may appear. Treatment is symptomatic and supportive; gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy: Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: It is unknown whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available, original patent expired
Clinical Trials
Clobetasol Propionate has been extensively studied in clinical trials for its efficacy and safety in various corticosteroid-responsive dermatoses.
Lab Monitoring
- Consider HPA axis evaluation (e.g., ACTH stimulation test, plasma cortisol levels) for patients on long-term or extensive topical corticosteroid therapy, especially children.
Doctor Notes
- Advise patients on appropriate application technique and duration.
- Monitor for signs of HPA axis suppression in high-risk patients.
- Avoid abrupt discontinuation after prolonged use on large areas.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Do not use for longer than the prescribed duration (typically 2 weeks).
- Avoid applying to large areas or under occlusive dressings unless advised.
- Wash hands before and after application.
- Inform your doctor if your condition worsens or does not improve.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. Do not apply a double dose to make up for a missed one.
Driving Precautions
Steclo-005-cream is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants that can worsen skin conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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