Strazyl
Generic Name
Azithromycin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| strazyl 200 mg suspension | ৳ 24.84 | N/A |
Description
Overview of the medicine
Strazyl 200 mg Suspension is a macrolide antibiotic used to treat a wide range of bacterial infections, including respiratory tract infections, skin and soft tissue infections, and certain sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For adults, typically 500 mg (12.5 mL of 200 mg/5 mL suspension) on day 1, followed by 250 mg (6.25 mL) once daily for 4 days, or 500 mg (12.5 mL) once daily for 3 days, depending on the infection. For children, dosage is usually 10 mg/kg once daily for 3 days or 10 mg/kg on day 1 followed by 5 mg/kg for 4 days, as directed by a pediatrician.
Elderly
No specific dose adjustment is generally required for elderly patients, but monitoring of renal and hepatic function is advisable.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment (creatinine clearance <10 mL/min).
How to Take
Strazyl Suspension should be taken orally, with or without food. Shake the bottle well before each use. Measure the dose accurately using the provided measuring device.
Mechanism of Action
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with the translation of mRNA.
Pharmacokinetics
Onset
Onset of action is typically within 2-3 hours.
Excretion
Mainly excreted unchanged in the bile; a smaller portion is excreted renally.
Half life
Approximately 68 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, however, absorption is decreased by food.
Metabolism
Minimally metabolized in the liver, primarily via N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any component of the formulation.
- Patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels have been reported with concomitant macrolide antibiotics.
Antacids
Concurrent administration with antacids containing aluminum or magnesium may reduce the peak serum concentrations of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Monitor INR closely in patients receiving concomitant azithromycin and warfarin due to increased anticoagulant effect.
Nelfinavir
May increase azithromycin serum concentrations.
Cyclosporine
Monitor cyclosporine levels and adjust dosage if co-administered with azithromycin.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves supportive and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any component of the formulation.
- Patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels have been reported with concomitant macrolide antibiotics.
Antacids
Concurrent administration with antacids containing aluminum or magnesium may reduce the peak serum concentrations of azithromycin. Administer azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Monitor INR closely in patients receiving concomitant azithromycin and warfarin due to increased anticoagulant effect.
Nelfinavir
May increase azithromycin serum concentrations.
Cyclosporine
Monitor cyclosporine levels and adjust dosage if co-administered with azithromycin.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves supportive and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the date of manufacture. Refer to the specific product packaging for exact shelf life.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across various bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Liver function tests (for prolonged therapy or in patients with pre-existing hepatic impairment)
- Renal function tests (in patients with severe renal impairment)
- INR (for patients on warfarin)
Doctor Notes
- Advise patients to always complete the full prescribed course of therapy to prevent antibiotic resistance and ensure complete eradication of the infection.
- Instruct patients to shake the suspension well before administering each dose to ensure uniform drug distribution.
- Educate parents/caregivers on proper dosage measurement for pediatric patients to avoid under- or over-dosing.
- Warn against the use of azithromycin for viral infections, as it is ineffective and contributes to antibiotic resistance.
Patient Guidelines
- Complete the full course of antibiotic treatment as prescribed by your doctor, even if you feel better.
- Do not save leftover medication for future infections.
- Shake the suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Strazyl 200 mg Suspension may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Ensure adequate hydration by drinking plenty of fluids.
- Rest as much as possible to aid recovery.
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