Strazyl
Generic Name
Linezolid
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| strazyl 400 mg tablet | ৳ 1.02 | ৳ 10.20 |
Description
Overview of the medicine
Strazyl 400 mg tablet contains Linezolid, an oxazolidinone antibiotic used to treat serious bacterial infections that are resistant to other antibiotics. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
600 mg every 12 hours for 10-14 consecutive days for most infections (e.g., VRE, nosocomial pneumonia). For complicated skin and skin structure infections, 400 mg or 600 mg every 12 hours.
Elderly
No dose adjustment necessary.
Renal_impairment
No dose adjustment needed for mild to severe renal impairment. Hemodialysis removes Linezolid; administer dose after dialysis.
How to Take
Strazyl 400 mg tablets can be taken with or without food. Swallow the tablet whole with a glass of water. Take it at regular intervals as prescribed by your doctor.
Mechanism of Action
Linezolid exerts its antibacterial activity by inhibiting bacterial protein synthesis. It binds to the 23S ribosomal RNA of the 50S ribosomal subunit, preventing the formation of a functional 70S initiation complex, which is essential for bacterial translation.
Pharmacokinetics
Onset
Rapid, therapeutic levels achieved within hours.
Excretion
Approximately 30% excreted in urine as unchanged drug, and about 50% as metabolites. A smaller portion excreted in feces.
Half life
Approximately 4-5 hours.
Absorption
Rapidly and extensively absorbed after oral administration; absolute bioavailability is approximately 100%. Peak plasma concentrations are reached in 1-2 hours.
Metabolism
Primarily metabolized by oxidation of the morpholine ring, resulting in two inactive carboxylic acid metabolites. Not metabolized by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Linezolid or any component of the formulation
- Patients taking MAO inhibitors or within two weeks of taking an MAO inhibitor
- Uncontrolled hypertension
- Pheochromocytoma
- Carcinoid syndrome
- Thyrotoxicosis
- Untreated hyperthyroidism
- Patients taking other serotonergic drugs unless carefully monitored
Drug Interactions
Serotonergic Agents
Risk of serotonin syndrome. Monitor for symptoms.
Tyramine-rich foods/drinks
Potential for hypertensive crisis due to weak MAO inhibition. Avoid large amounts.
Adrenergic and Dopaminergic Agents
Potentiation of vasopressor effects. Monitor blood pressure.
Monoamine Oxidase Inhibitors (MAOIs)
Linezolid is a reversible, non-selective MAOI. Concomitant use with other MAOIs is contraindicated.
Storage
Store at room temperature, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be taken. Hemodialysis may remove Linezolid, but it is not sufficient for rapid removal.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies the potential risk to the fetus. Lactation: Excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Linezolid or any component of the formulation
- Patients taking MAO inhibitors or within two weeks of taking an MAO inhibitor
- Uncontrolled hypertension
- Pheochromocytoma
- Carcinoid syndrome
- Thyrotoxicosis
- Untreated hyperthyroidism
- Patients taking other serotonergic drugs unless carefully monitored
Drug Interactions
Serotonergic Agents
Risk of serotonin syndrome. Monitor for symptoms.
Tyramine-rich foods/drinks
Potential for hypertensive crisis due to weak MAO inhibition. Avoid large amounts.
Adrenergic and Dopaminergic Agents
Potentiation of vasopressor effects. Monitor blood pressure.
Monoamine Oxidase Inhibitors (MAOIs)
Linezolid is a reversible, non-selective MAOI. Concomitant use with other MAOIs is contraindicated.
Storage
Store at room temperature, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be taken. Hemodialysis may remove Linezolid, but it is not sufficient for rapid removal.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies the potential risk to the fetus. Lactation: Excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, depending on manufacturer and storage conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Linezolid in various Gram-positive bacterial infections, including those resistant to other antibiotics.
Lab Monitoring
- Complete blood count (CBC) weekly, especially for thrombocytopenia
- Liver function tests (LFTs) periodically
- Renal function tests periodically
- Visual acuity and color vision tests for prolonged therapy (>28 days)
Doctor Notes
- Monitor CBC weekly, especially for patients on prolonged therapy.
- Advise patients to report any visual changes immediately.
- Be aware of potential for serotonin syndrome when co-administering with serotonergic agents.
- Counsel patients on dietary restrictions regarding tyramine-rich foods.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor, even if you feel better.
- Do not stop taking the medication early, as it may lead to recurrence of infection and antibiotic resistance.
- Report any visual changes (e.g., blurred vision, changes in color vision) to your doctor immediately.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Avoid large amounts of tyramine-rich foods.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or vision changes. Exercise caution when driving or operating machinery until you know how Strazyl affects you.
Lifestyle Advice
- Maintain good hygiene to prevent spread of infection.
- Drink plenty of fluids to stay hydrated.
- Complete the full course of antibiotics as prescribed.
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