Sudac
Generic Name
Diclofenac Sodium
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sudac 100 mg tablet | ৳ 5.50 | ৳ 55.00 |
Description
Overview of the medicine
Sudac 100 mg Tablet contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID), used for pain relief, reduction of inflammation, and fever. It is commonly prescribed for conditions like arthritis, muscle pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
Usually 100 mg once daily (sustained release). For immediate release, 50 mg 2-3 times daily. Max 150 mg/day.
Elderly
Use lowest effective dose. Monitor for adverse effects, especially GI and renal.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment. Not recommended in severe renal failure.
How to Take
Swallow the tablet whole with water, preferably with or after food to minimize gastrointestinal upset. Do not chew or crush sustained-release tablets.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By inhibiting their synthesis, diclofenac reduces these symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes for pain relief.
Excretion
Excreted primarily through the urine (approximately 60%) and bile/feces (approximately 35%).
Half life
Approximately 1-2 hours (terminal half-life), though metabolites have longer half-lives.
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached in 2-3 hours for conventional tablets.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9 and UGT enzymes, to inactive and active metabolites.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding
Lithium, Methotrexate
Increased plasma levels, increased toxicity
Warfarin, other anticoagulants
Increased risk of bleeding
Diuretics, ACE inhibitors, Angiotensin II receptor blockers
Reduced antihypertensive effect, increased risk of renal impairment
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding. Management is primarily supportive; gastric lavage, activated charcoal, and symptomatic treatment may be considered.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid during late pregnancy due to potential fetal cardiovascular effects. Diclofenac passes into breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding
Lithium, Methotrexate
Increased plasma levels, increased toxicity
Warfarin, other anticoagulants
Increased risk of bleeding
Diuretics, ACE inhibitors, Angiotensin II receptor blockers
Reduced antihypertensive effect, increased risk of renal impairment
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding. Management is primarily supportive; gastric lavage, activated charcoal, and symptomatic treatment may be considered.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid during late pregnancy due to potential fetal cardiovascular effects. Diclofenac passes into breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, check specific packaging for details.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory bodies worldwide, including DGDA (Bangladesh)
Patent Status
Generally off-patent, available as generics
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of diclofenac for its approved indications.
Lab Monitoring
- Complete blood count (CBC)
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Blood pressure monitoring
Doctor Notes
- Advise patients on the lowest effective dose for the shortest duration necessary.
- Counsel patients about the signs and symptoms of GI bleeding and cardiovascular events.
- Consider concomitant use of proton pump inhibitors for patients at high GI risk.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual bleeding, stomach pain, or dark stools to your doctor immediately.
- Avoid concurrent use of other NSAIDs unless directed by a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; if affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption, which can increase the risk of stomach bleeding.
- Maintain adequate hydration.
- Discuss any pre-existing medical conditions, especially heart or kidney disease, with your doctor.
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Global Brand Names
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