Sugatrol
Generic Name
Glibetrol Sodium
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
sugatrol 100 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Sugatrol 100 mg Tablet is an oral antidiabetic medication used to improve glycemic control in adults with type 2 diabetes mellitus. It works by increasing the excretion of glucose in the urine.
Uses & Indications
Dosage
Adults
Initial dose 100 mg once daily, taken in the morning. May be adjusted based on glycemic response and tolerability.
Elderly
No dose adjustment required based on age alone; consider renal function.
Renal_impairment
Not recommended for eGFR < 30 mL/min/1.73 m².
How to Take
Oral administration, once daily in the morning, with or without food. Swallow the tablet whole.
Mechanism of Action
Sugatrol is a selective SGLT2 inhibitor. By inhibiting SGLT2, it reduces glucose reabsorption in the renal tubules, leading to increased urinary glucose excretion and a reduction in blood glucose levels.
Pharmacokinetics
Onset
Glycemic effects typically observed within hours of first dose.
Excretion
Excreted renally as metabolites and minimally as unchanged drug.
Half life
Approximately 10-13 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- End-stage renal disease
- Dialysis
Drug Interactions
Lithium
May decrease lithium serum concentrations.
Diuretics
Increased risk of dehydration and hypotension.
Insulin and Insulin Secretagogues
Increased risk of hypoglycemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to dehydration and electrolyte imbalance. Management should be supportive, focusing on fluid and electrolyte correction.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal renal abnormalities. Avoid during lactation; discontinue breastfeeding or the drug.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- End-stage renal disease
- Dialysis
Drug Interactions
Lithium
May decrease lithium serum concentrations.
Diuretics
Increased risk of dehydration and hypotension.
Insulin and Insulin Secretagogues
Increased risk of hypoglycemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to dehydration and electrolyte imbalance. Management should be supportive, focusing on fluid and electrolyte correction.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal renal abnormalities. Avoid during lactation; discontinue breastfeeding or the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies and Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patent Pending
Clinical Trials
Extensive clinical trials (Phase I, II, III) have demonstrated the efficacy and safety of Sugatrol in managing type 2 diabetes.
Lab Monitoring
- Renal function (eGFR) before initiation and periodically during treatment
- Blood glucose levels
- Glycated hemoglobin (HbA1c)
Doctor Notes
- Educate patients on symptoms of DKA and genital infections.
- Monitor renal function regularly.
- Emphasize hydration to prevent dehydration.
Patient Guidelines
- Take as directed by your doctor.
- Maintain adequate hydration.
- Report any signs of genital or urinary tract infection immediately.
- Monitor blood glucose regularly.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Sugatrol generally does not affect the ability to drive or operate machinery. However, if symptoms like dizziness or hypoglycemia occur (especially in combination with insulin or sulfonylureas), caution is advised.
Lifestyle Advice
- Follow a balanced diet.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Regular foot care is important.
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