Sugel
Generic Name
Sugel 175 mg Suspension
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sugel 175 mg suspension | ৳ 55.00 | N/A |
Description
Overview of the medicine
Sugel 175 mg Suspension is a broad-spectrum antibiotic indicated for the treatment of various bacterial infections. It works by inhibiting bacterial DNA replication, thus killing the bacteria.
Uses & Indications
Dosage
Adults
The usual recommended dose is 175 mg (5 ml) orally twice daily for 7-14 days, depending on the severity and type of infection.
Elderly
No specific dose adjustment is generally required, but caution should be exercised in patients with renal impairment.
Renal_impairment
For creatinine clearance <30 mL/min, the dose should be reduced to 175 mg (5 ml) once daily.
How to Take
Shake the bottle well before each use. Administer orally, preferably with a meal to minimize gastrointestinal upset. Complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
Mechanism of Action
The active ingredient in Sugel, Xylomoxifloxacin (fictional), belongs to the fluoroquinolone class. It inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Excreted mainly via urine (approximately 50-60%) and feces (approximately 30-40%) within 24-48 hours.
Half life
Approximately 6-8 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Xylomoxifloxacin (fictional) or any other fluoroquinolone.
- History of tendon disorders related to fluoroquinolone administration.
- Epilepsy or other seizure disorders.
Drug Interactions
NSAIDs
Concomitant use may increase the risk of CNS stimulation and convulsions.
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Theophylline
Increased risk of theophylline toxicity.
Antacids (containing magnesium, aluminum) & Iron supplements
May reduce the absorption of Sugel. Administer Sugel at least 2 hours before or 4 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct light. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, dizziness, confusion, and possibly convulsions. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Sugel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Xylomoxifloxacin (fictional) or any other fluoroquinolone.
- History of tendon disorders related to fluoroquinolone administration.
- Epilepsy or other seizure disorders.
Drug Interactions
NSAIDs
Concomitant use may increase the risk of CNS stimulation and convulsions.
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Theophylline
Increased risk of theophylline toxicity.
Antacids (containing magnesium, aluminum) & Iron supplements
May reduce the absorption of Sugel. Administer Sugel at least 2 hours before or 4 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct light. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, dizziness, confusion, and possibly convulsions. Treatment should be symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Sugel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date when stored unopened. Once opened, use within 14 days.
Availability
Available in pharmacies and hospitals nationwide.
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Phase III clinical trials demonstrated efficacy and safety in the treatment of various bacterial infections. Further post-marketing surveillance is ongoing.
Lab Monitoring
- Renal function tests (for prolonged therapy or in renally impaired patients)
- Liver function tests (for prolonged therapy)
Doctor Notes
- Emphasize the importance of completing the full course to prevent antibiotic resistance.
- Educate patients on potential serious adverse reactions like tendon rupture and peripheral neuropathy, and advise immediate discontinuation if symptoms occur.
- Consider drug interactions, especially with antacids, iron, and warfarin.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if you feel better.
- Avoid direct sun exposure or use protective clothing and sunscreen, as Sugel may increase photosensitivity.
- Report any unusual pain, tingling, numbness, or weakness immediately to your doctor.
- Do not take antacids or iron supplements within 2 hours before or 4 hours after taking Sugel.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Sugel may cause dizziness or lightheadedness. Patients should be advised to exercise caution when driving or operating machinery until they know how Sugel affects them.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid strenuous physical activity that may stress tendons during treatment.
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