Take orally with a glass of water, with or without food. Taking with food or milk may reduce stomach upset. Drink plenty of fluids to prevent crystalluria.

Sulfamethoxazole inhibits bacterial dihydrofolate synthesis, and trimethoprim inhibits bacterial dihydrofolate reductase, leading to sequential blockade of the bacterial folic acid pathway and bactericidal action.

• •Known hypersensitivity to sulfamethoxazole, trimethoprim, or any excipients
• •Severe renal or hepatic impairment
• •Megaloblastic anemia due to folate deficiency
• •Infants less than 2 months of age
• •Porphyria

Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of acute overdose include nausea, vomiting, dizziness, and mental confusion. Chronic overdose can lead to bone marrow depression. Treatment is symptomatic and supportive; gastric lavage, forced diuresis, and hemodialysis may be considered.

Pregnancy Category C (D if used in late pregnancy). Contraindicated in late pregnancy due to risk of kernicterus in the neonate. Excreted in breast milk; use with caution during lactation, monitor infant for rash and diarrhea.