Superpime
Generic Name
Cefepime 1 gm Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| superpime 1 gm injection | ৳ 551.64 | N/A |
Description
Overview of the medicine
Superpime 1 gm Injection contains Cefepime, a broad-spectrum, fourth-generation cephalosporin antibiotic used to treat a variety of serious bacterial infections, including pneumonia, urinary tract infections, complicated intra-abdominal infections, and febrile neutropenia.
Uses & Indications
Dosage
Adults
Typically 1-2 gm IV/IM every 8-12 hours, depending on the severity and type of infection. For febrile neutropenia, 2 gm IV every 8 hours.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
Significant dosage reduction is required based on creatinine clearance. For example, for creatinine clearance 30-60 mL/min, 1 gm every 24 hours; for 11-29 mL/min, 0.5 gm every 24 hours.
How to Take
Administered intravenously (IV) over 30 minutes or intramuscularly (IM) into a large muscle mass. The powder must be reconstituted with an appropriate diluent (e.g., sterile water for injection, 0.9% sodium chloride).
Mechanism of Action
Cefepime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan units, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Rapid, typically within minutes after intravenous administration.
Excretion
Primarily excreted by the kidneys (approximately 85% as unchanged drug in urine).
Half life
Approximately 2 hours in adults with normal renal function.
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations are achieved rapidly after IV infusion.
Metabolism
Not extensively metabolized. A small fraction is hydrolyzed to N-methylpyrrolidine, which is then rapidly converted to N-methylpyrrolidine N-oxide.
Side Effects
Contraindications
- Hypersensitivity to cefepime or any component of the formulation.
- Hypersensitivity to other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to any other beta-lactam antibacterial agents (e.g., penicillins, carbapenems).
Drug Interactions
Aminoglycosides
Concurrent use may increase the risk of nephrotoxicity and ototoxicity. Monitor renal function closely.
Loop Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity when co-administered with cephalosporins.
Oral Anticoagulants (e.g., Warfarin)
Cephalosporins may enhance the anticoagulant effect; monitor INR/PT time.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored as per manufacturer's instructions.
Overdose
Symptoms of overdose may include encephalopathy, seizures, and neuromuscular excitability. In case of overdose, discontinue cefepime and provide supportive treatment. Hemodialysis may be useful in accelerating the removal of cefepime from the body.
Pregnancy & Lactation
Pregnancy Category B. Cefepime should be used during pregnancy only if clearly needed. It is excreted in human milk in very low concentrations; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cefepime or any component of the formulation.
- Hypersensitivity to other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to any other beta-lactam antibacterial agents (e.g., penicillins, carbapenems).
Drug Interactions
Aminoglycosides
Concurrent use may increase the risk of nephrotoxicity and ototoxicity. Monitor renal function closely.
Loop Diuretics (e.g., Furosemide)
May increase the risk of nephrotoxicity when co-administered with cephalosporins.
Oral Anticoagulants (e.g., Warfarin)
Cephalosporins may enhance the anticoagulant effect; monitor INR/PT time.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Reconstituted solution should be used immediately or stored as per manufacturer's instructions.
Overdose
Symptoms of overdose may include encephalopathy, seizures, and neuromuscular excitability. In case of overdose, discontinue cefepime and provide supportive treatment. Hemodialysis may be useful in accelerating the removal of cefepime from the body.
Pregnancy & Lactation
Pregnancy Category B. Cefepime should be used during pregnancy only if clearly needed. It is excreted in human milk in very low concentrations; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months from the date of manufacture. Refer to the specific product packaging for exact details.
Availability
Hospitals, Registered Pharmacies
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefepime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different patient populations, leading to its widespread approval and use.
Lab Monitoring
- Monitor renal function (creatinine, BUN) before and during therapy, especially in patients with pre-existing renal impairment.
- Monitor complete blood count (CBC) with differential, especially during prolonged therapy.
- Liver function tests may be monitored if clinically indicated.
Doctor Notes
- Careful dose adjustment is crucial in patients with impaired renal function to prevent accumulation and neurotoxicity.
- Monitor for signs of Clostridioides difficile-associated diarrhea (CDAD) during and after therapy.
- Cefepime is a valuable agent for empiric therapy in febrile neutropenia due to its broad spectrum and efficacy against common pathogens.
Patient Guidelines
- Inform your doctor about any known allergies, especially to antibiotics.
- Complete the full course of injection as prescribed, even if symptoms improve.
- Report any unusual or severe side effects to your healthcare provider immediately.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefepime may cause dizziness or seizures in some patients, which could impair the ability to drive or operate machinery. Patients should be advised to exercise caution.
Lifestyle Advice
- Maintain adequate hydration during therapy.
- Avoid self-medication.
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