Supraxim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| supraxim 100 mg suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Supraxim 100 mg Suspension is an oral antibiotic belonging to the cephalosporin group. It is used to treat a wide range of bacterial infections, including those of the respiratory tract, urinary tract, ear, nose, and throat.
Uses & Indications
Dosage
Adults
Primarily for pediatric use. For children, the recommended dose is 8 mg/kg/day, given as a single daily dose or in two divided doses every 12 hours. For example, a child weighing 12.5 kg would take 5 ml (100 mg) once daily or 2.5 ml (50 mg) twice daily.
Elderly
No specific dose adjustment necessary for elderly patients with normal renal function. Close monitoring is advised for renal impairment.
Renal_impairment
For creatinine clearance 21-60 mL/min, dose should be reduced by 25%. For creatinine clearance <20 mL/min, dose should be reduced by 50%. Hemodialysis or peritoneal dialysis patients: use same dose as those with creatinine clearance <20 mL/min.
How to Take
Shake the bottle well before each use. Measure the dose accurately using the provided measuring spoon or cup. Can be taken with or without food. Complete the full course of medication as prescribed, even if symptoms improve.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis.
Pharmacokinetics
Onset
1-2 hours
Excretion
Mainly via urine (about 50-60% of absorbed dose) and bile.
Half life
3-4 hours
Absorption
Approximately 30-50% orally absorbed. Food slightly delays absorption but does not significantly affect the extent.
Metabolism
Limited hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of serious allergic reactions to penicillins (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase anticoagulant effect; monitor INR.
Probenecid
May increase cefixime plasma levels.
Oral Contraceptives
May reduce efficacy of oral contraceptives (rarely reported).
Storage
Store dry powder below 30°C in a dry place, away from light. Keep the reconstituted suspension refrigerated (2°C-8°C) and discard any unused portion after 7 or 14 days (check specific brand instructions). Do not freeze.
Overdose
Gastric lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treat symptomatically and supportively.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of serious allergic reactions to penicillins (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase anticoagulant effect; monitor INR.
Probenecid
May increase cefixime plasma levels.
Oral Contraceptives
May reduce efficacy of oral contraceptives (rarely reported).
Storage
Store dry powder below 30°C in a dry place, away from light. Keep the reconstituted suspension refrigerated (2°C-8°C) and discard any unused portion after 7 or 14 days (check specific brand instructions). Do not freeze.
Overdose
Gastric lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treat symptomatically and supportively.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years for dry powder. Reconstituted suspension is stable for 7-14 days when stored at room temperature or refrigerated, depending on manufacturer guidelines.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime in various bacterial infections, particularly in pediatric populations. Ongoing research explores its role in emerging antimicrobial resistance patterns.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with impaired renal function
- INR/PT for patients on warfarin
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Emphasize completing the full course of treatment to prevent resistance.
- Advise parents on proper measurement and administration techniques for suspension.
- Monitor for signs of C. difficile infection if diarrhea is severe or persistent after treatment.
Patient Guidelines
- Take the full course of medication as prescribed.
- Shake the suspension well before each use.
- Use the provided measuring device for accurate dosing.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, cefixime does not impair the ability to drive or operate machinery. However, if dizziness occurs, caution should be exercised.
Lifestyle Advice
- Maintain good hydration.
- Avoid self-medication with antibiotics.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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