Medicine Information

Supraxim

Name: Supraxim
Brand: Supraxim
Rating: 4.5 (117 reviews)

Capsule200 mgAntibiotics (3rd Generation Cephalosporins)ATC: J01DD08

Generic Name

Cefixime

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
supraxim 200 mg capsule	৳ 35.00	৳ 210.00

Description

Overview of the medicine

Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections susceptible to cefixime.

Uses & Indications

Uncomplicated urinary tract infections (UTIs)

Otitis media

Pharyngitis and tonsillitis

Acute bronchitis and acute exacerbations of chronic bronchitis

Uncomplicated gonorrhea (cervical/urethral)

Dosage

Adults

The usual adult dose is 200 mg once daily or 100 mg twice daily. For severe infections or infections caused by less susceptible organisms, the dose may be increased to 400 mg once daily.

Elderly

No dosage adjustment is necessary for elderly patients unless they have severe renal impairment.

Renal_impairment

For creatinine clearance 21-60 mL/min, the dose should be reduced to 75% of the standard dose. For creatinine clearance <20 mL/min, the dose should be reduced to 50% of the standard dose.

How to Take

Supraxim-200-mg-capsule should be taken orally. It can be taken with or without food. Taking it with food may help reduce gastrointestinal upset.

Mechanism of Action

Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis, leading to bacterial cell lysis and death.

Pharmacokinetics

Onset

Peak plasma concentrations are achieved within 2 to 6 hours after a single 200 mg dose.

Excretion

Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. Non-renal clearance accounts for about 10% of total clearance.

Half life

Plasma half-life is typically 3 to 4 hours, which may be prolonged in patients with renal impairment.

Absorption

Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly alter the extent of absorption.

Metabolism

Cefixime undergoes limited hepatic metabolism.

Side Effects

Contraindications

Hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reaction to penicillin.

Drug Interactions

Nifedipine

May increase the absorption of cefixime.

Carbamazepine

Cefixime may increase carbamazepine plasma levels, necessitating monitoring.

Warfarin and other anticoagulants

Cefixime may increase prothrombin time (INR), requiring careful monitoring and possible dose adjustment of anticoagulants.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment should be given.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use in pregnancy only if clearly needed. Caution should be exercised when cefixime is administered to a nursing mother as it is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 10 capsules2 x 10 capsules

Shelf Life

Usually 24 to 36 months from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved by DGDA/FDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has been extensively studied in numerous clinical trials demonstrating its efficacy and safety profile across various bacterial infections in adults and pediatric populations.

Lab Monitoring

Renal function tests (e.g., creatinine clearance) should be monitored in patients with pre-existing renal impairment or during prolonged therapy.
Complete blood count (CBC) should be monitored during prolonged high-dose therapy.
Prothrombin time/INR should be monitored in patients concurrently taking anticoagulants.

Doctor Notes

Emphasize the importance of completing the full course of therapy to patients to prevent antibiotic resistance.
Monitor for signs of Clostridium difficile-associated diarrhea (CDAD), which can occur even weeks after cessation of therapy.
Assess for history of penicillin allergy before prescribing, due to potential for cross-hypersensitivity.

Patient Guidelines

Take the medicine for the full prescribed duration, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
Do not share this medication with others, as it may be ineffective or harmful for their condition.
Report any persistent or severe diarrhea, skin rash, or allergic reactions to your doctor immediately.
Drink plenty of fluids unless otherwise advised by your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Cefixime is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or headache, caution should be exercised.