Sylvia ODT
Generic Name
Desloratadine
Manufacturer
Medicon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| sylvia odt 75 mg tablet | ৳ 150.00 | ৳ 600.00 |
Description
Overview of the medicine
Sylvia ODT contains desloratadine, a non-sedating antihistamine, used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.
Uses & Indications
Dosage
Adults
5 mg (one ODT) once daily.
Elderly
No dosage adjustment generally required, but caution in patients with renal or hepatic impairment.
Renal_impairment
5 mg every other day for severe renal impairment.
How to Take
Place the orally disintegrating tablet on the tongue. It will dissolve rapidly and can be swallowed with or without water. Take with or without food.
Mechanism of Action
Desloratadine is a potent, selective, peripheral histamine H1-receptor antagonist. It inhibits the release of histamine from mast cells and blocks the action of histamine, thereby reducing allergic symptoms.
Pharmacokinetics
Onset
Within 30 minutes
Excretion
Excreted through urine and feces as metabolites.
Half life
Approximately 27 hours
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Severe renal impairment.
Drug Interactions
Cimetidine
May increase desloratadine plasma concentrations.
Erythromycin
May increase desloratadine plasma concentrations.
Ketoconazole
May increase desloratadine plasma concentrations.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, somnolence, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as desloratadine is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Severe renal impairment.
Drug Interactions
Cimetidine
May increase desloratadine plasma concentrations.
Erythromycin
May increase desloratadine plasma concentrations.
Ketoconazole
May increase desloratadine plasma concentrations.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, somnolence, and headache. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Caution advised during lactation as desloratadine is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established its efficacy and safety for allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No specific routine lab monitoring required.
- Liver function tests if hepatic impairment suspected.
Doctor Notes
- Remind patients that it's a non-sedating antihistamine, but some individuals might experience mild drowsiness.
- Advise caution in patients with hepatic or renal impairment, requiring dosage adjustment.
- Emphasize proper administration of ODTs.
Patient Guidelines
- Do not crush or chew the ODT; allow it to dissolve on the tongue.
- Take with or without food.
- Inform your doctor about all existing medical conditions and medications.
- Do not exceed the recommended dose.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Generally non-sedating, but caution advised until individual response is known, as some individuals may experience drowsiness. Avoid driving or operating heavy machinery if affected.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Stay hydrated.
- Maintain good indoor air quality.
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Global Brand Names
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