T-Zol
Generic Name
Tioconazole
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| t zol 1 gm tablet | ৳ 5.75 | ৳ 23.00 |
Description
Overview of the medicine
Tioconazole 1 gm vaginal tablet is an antifungal medication used for the local treatment of vulvovaginal candidiasis (yeast infections) caused by Candida species.
Uses & Indications
Dosage
Adults
Insert one 1 gm vaginal tablet deep into the vagina as a single dose, preferably at bedtime.
Elderly
No specific dosage adjustment is required for elderly patients; use as for adults.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment due to minimal systemic absorption.
How to Take
The vaginal tablet should be inserted as deeply as possible into the vagina, preferably at bedtime. An applicator may be provided to aid insertion.
Mechanism of Action
Tioconazole works by altering the permeability of the fungal cell membrane. It inhibits the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to increased permeability, leakage of cellular contents, and eventual death of fungal cells.
Pharmacokinetics
Onset
Symptom improvement usually begins within 2-3 days following administration.
Excretion
Systemically absorbed Tioconazole is primarily excreted via urine and feces; however, the amount is negligible due to minimal absorption.
Half life
Systemic half-life is not clinically relevant due to very low systemic absorption; local action is predominant.
Absorption
Minimal systemic absorption occurs after vaginal administration. Less than 10% of the dose is absorbed systemically.
Metabolism
Minimal systemic metabolism occurs due to low absorption.
Side Effects
Contraindications
- Hypersensitivity to Tioconazole or any other imidazole antifungal agents.
- Known allergy to any component of the formulation.
Drug Interactions
Warfarin
Although systemic absorption is minimal, there have been rare reports of increased anticoagulant effect when vaginal imidazole antifungals are used concomitantly with oral anticoagulants like warfarin. Monitor INR if co-administration is necessary.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose with topical vaginal Tioconazole is highly unlikely due to minimal systemic absorption. In the event of accidental oral ingestion, general supportive measures should be taken.
Pregnancy & Lactation
Pregnancy Category C. Tioconazole vaginal tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor. Use with caution during lactation; minimal systemic absorption suggests low risk, but prudence is advised.
Side Effects
Contraindications
- Hypersensitivity to Tioconazole or any other imidazole antifungal agents.
- Known allergy to any component of the formulation.
Drug Interactions
Warfarin
Although systemic absorption is minimal, there have been rare reports of increased anticoagulant effect when vaginal imidazole antifungals are used concomitantly with oral anticoagulants like warfarin. Monitor INR if co-administration is necessary.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose with topical vaginal Tioconazole is highly unlikely due to minimal systemic absorption. In the event of accidental oral ingestion, general supportive measures should be taken.
Pregnancy & Lactation
Pregnancy Category C. Tioconazole vaginal tablet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor. Use with caution during lactation; minimal systemic absorption suggests low risk, but prudence is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on the manufacturer.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Off-patent
Clinical Trials
Clinical trials have established the efficacy and safety profile of Tioconazole 1 gm vaginal tablet in the treatment of vulvovaginal candidiasis, demonstrating high cure rates and good tolerability.
Lab Monitoring
- Routine lab monitoring is generally not required for localized vaginal treatment with Tioconazole.
Doctor Notes
- Advise patients on the correct method of vaginal tablet insertion to ensure maximum efficacy.
- Emphasize that this is a single-dose treatment and no further doses should be used unless symptoms persist or re-occur, requiring further consultation.
- Counsel patients on hygiene practices to prevent recurrent infections.
Patient Guidelines
- Use the tablet exactly as directed by your doctor or as per package instructions.
- Insert the tablet deep into the vagina, preferably at bedtime, for optimal efficacy.
- Do not use during menstruation without consulting a doctor, as efficacy may be affected.
Missed Dose Advice
As T-Zol 1 gm tablet is a single-dose treatment, a missed dose is not applicable. If symptoms persist or worsen after treatment, consult your doctor.
Driving Precautions
T-Zol vaginal tablet has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Wear cotton underwear and avoid tight-fitting clothing to allow proper air circulation.
- Practice good personal hygiene to prevent recurrence of vaginal infections.
- Avoid douching as it can upset the natural balance of vaginal flora.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in T-Zol Brand
Other medicines available under the same brand name
