T-Zol
Generic Name
Tinidazole 500 mg Tablet
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| t zol 500 mg tablet | ৳ 2.77 | ৳ 27.67 |
Description
Overview of the medicine
Tinidazole is an antiprotozoal and antibacterial medication used to treat various infections caused by susceptible organisms, including amoebiasis, giardiasis, trichomoniasis, and certain anaerobic bacterial infections.
Uses & Indications
Dosage
Adults
Dosage varies with infection type. For amoebiasis: 2 g once daily for 2-3 days or 500 mg twice daily for 5-7 days. For trichomoniasis/giardiasis: single 2 g dose.
Elderly
No specific dosage adjustment required, but consider overall health and renal function.
Renal_impairment
Dose adjustment may be necessary in patients with severe renal impairment (creatinine clearance < 22 ml/min).
How to Take
Take orally, preferably with or after food, to minimize gastrointestinal discomfort. Swallow the tablet whole with water.
Mechanism of Action
Tinidazole exerts its effects by entering the cell of anaerobic and protozoal organisms. Once inside, it is reduced to active metabolites that interact with DNA, causing DNA strand breakage and inhibition of nucleic acid synthesis, leading to cell death.
Pharmacokinetics
Onset
Within 1-2 hours for therapeutic effect.
Excretion
Excreted primarily through the kidneys (unchanged drug and metabolites) and also via faeces.
Half life
Approximately 12-14 hours, allowing for once-daily dosing in many cases.
Absorption
Rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached within 2 hours.
Metabolism
Partially metabolized in the liver, primarily by oxidation.
Side Effects
Contraindications
- Hypersensitivity to tinidazole or other nitroimidazole derivatives.
- First trimester of pregnancy.
- Patients with active neurological disorders or a history of blood dyscrasias.
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, flushing, headaches) if consumed during or within 72 hours of treatment.
Lithium
May increase serum lithium levels, leading to toxicity.
Oral Anticoagulants (e.g., Warfarin)
May potentiate the anticoagulant effect, requiring dose adjustment and increased monitoring.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include severe gastrointestinal upset, ataxia, and neurological symptoms. Management involves symptomatic and supportive care. No specific antidote is available. Hemodialysis may be helpful.
Pregnancy & Lactation
Contraindicated in the first trimester of pregnancy. Use in the second and third trimesters only if clearly needed and potential benefits outweigh risks. Not recommended during lactation; mothers should discontinue breastfeeding if treatment is essential.
Side Effects
Contraindications
- Hypersensitivity to tinidazole or other nitroimidazole derivatives.
- First trimester of pregnancy.
- Patients with active neurological disorders or a history of blood dyscrasias.
Drug Interactions
Alcohol
Disulfiram-like reaction (abdominal cramps, nausea, vomiting, flushing, headaches) if consumed during or within 72 hours of treatment.
Lithium
May increase serum lithium levels, leading to toxicity.
Oral Anticoagulants (e.g., Warfarin)
May potentiate the anticoagulant effect, requiring dose adjustment and increased monitoring.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include severe gastrointestinal upset, ataxia, and neurological symptoms. Management involves symptomatic and supportive care. No specific antidote is available. Hemodialysis may be helpful.
Pregnancy & Lactation
Contraindicated in the first trimester of pregnancy. Use in the second and third trimesters only if clearly needed and potential benefits outweigh risks. Not recommended during lactation; mothers should discontinue breastfeeding if treatment is essential.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Tinidazole has undergone extensive clinical trials demonstrating its efficacy and safety in various protozoal and anaerobic bacterial infections since its introduction.
Lab Monitoring
- Complete blood count (especially with prolonged therapy)
- Liver function tests (if hepatic impairment is suspected)
Doctor Notes
- Emphasize strict avoidance of alcohol during treatment and for at least 72 hours post-therapy due to disulfiram-like reaction.
- Counsel patients on potential neurological side effects like dizziness and peripheral neuropathy, especially with prolonged use.
- Consider liver function tests and complete blood counts for patients on extended courses.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve.
- Avoid alcohol during treatment and for at least 3 days after the last dose.
- Inform your doctor if you experience any unusual symptoms, especially neurological ones.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; avoid driving or operating heavy machinery if affected.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Ensure adequate hydration.
- Get sufficient rest.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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