Tapenta
Generic Name
Tapentadol
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tapenta 50 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Tapentadol is an opioid pain reliever used to treat moderate to severe acute and chronic pain. It acts through a dual mechanism: as a mu-opioid receptor agonist and a noradrenaline reuptake inhibitor.
Uses & Indications
Dosage
Adults
Immediate-release: 50 mg every 4-6 hours, as needed. Max 600 mg/day. Extended-release: Individualized dosing based on pain severity and patient response.
Elderly
Initiate with lower doses and titrate carefully, considering potential for decreased hepatic/renal function and concomitant medications.
Renal_impairment
Severe renal impairment (CrCl < 30 mL/min): initiate with 50 mg every 8 hours, and consider reducing subsequent doses. Not recommended for end-stage renal disease.
How to Take
Administer orally, with or without food. Swallow tablets whole, do not crush, chew, or break.
Mechanism of Action
Tapentadol is a centrally acting analgesic with a dual mode of action: it is a mu-opioid receptor agonist and a noradrenaline reuptake inhibitor. These actions contribute to its analgesic effects.
Pharmacokinetics
Onset
Approximately 30 minutes.
Excretion
Mainly excreted in urine (99%), predominantly as metabolites.
Half life
About 4 hours (for immediate-release formulation).
Absorption
Rapidly absorbed, with absolute bioavailability of about 32% (due to extensive first-pass metabolism). Peak plasma concentrations reached within 1.25 hours.
Metabolism
Primarily metabolized via glucuronidation to inactive metabolites. Minor metabolism by CYP2C9, CYP2C19, and CYP2D6.
Side Effects
Contraindications
- •Significant respiratory depression
- •Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- •Known or suspected paralytic ileus
- •Concomitant use in patients receiving monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
- •Hypersensitivity to tapentadol or any component of the formulation
Drug Interactions
MAO Inhibitors
Increased risk of serotonin syndrome or severe excitatory effects. Contraindicated.
Serotonergic Drugs (e.g., SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., benzodiazepines, alcohol)
Increased risk of profound sedation, respiratory depression, coma, and death.
Mixed Agonist/Antagonist Opioids (e.g., nalbuphine, buprenorphine)
May reduce the analgesic effect of tapentadol and/or precipitate withdrawal symptoms.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and possibly death. Treatment involves maintaining a patent airway, providing ventilatory support, and administering opioid antagonists like naloxone.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy, especially prolonged use, due to risk of neonatal opioid withdrawal syndrome. Not recommended during breastfeeding as tapentadol is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
FDA approved
Patent Status
Patent expired, generics available
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Global Brand Names
International brand names for this medicine
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