Targocid
Generic Name
Teicoplanin
Manufacturer
Sanofi-Aventis
Country
France
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| targocid 200 mg injection | ৳ 1,090.00 | N/A |
Description
Overview of the medicine
Targocid 200 mg Injection contains Teicoplanin, a glycopeptide antibiotic used to treat serious Gram-positive bacterial infections, particularly those resistant to other antibiotics like MRSA. It is administered intravenously or intramuscularly.
Uses & Indications
Dosage
Adults
Initial loading dose of 6-10 mg/kg IV every 12 hours for 3 doses, followed by a maintenance dose of 6-10 mg/kg IV or IM once daily. Doses depend on infection severity and site.
Elderly
Similar to adults, but careful monitoring of renal function and dose adjustment may be necessary due to age-related renal decline.
Renal_impairment
Significant dose reduction required based on creatinine clearance. Loading doses may remain the same, but maintenance doses and dosing frequency must be adjusted.
How to Take
Administered as an intravenous (IV) bolus (over 3-5 minutes), intravenous infusion (over 30 minutes), or intramuscular (IM) injection. Reconstitute the powder with the provided solvent before use.
Mechanism of Action
Teicoplanin inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala precursors, preventing peptidoglycan polymerization, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Rapid onset after IV administration (within minutes to hours).
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration.
Half life
Long elimination half-life, typically 70-100 hours in adults with normal renal function.
Absorption
Poorly absorbed orally; high bioavailability after intravenous or intramuscular administration.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Teicoplanin or any glycopeptide antibiotics
- Previous hypersensitivity to vancomycin (potential cross-reactivity)
Drug Interactions
Aminoglycosides (e.g., Gentamicin)
Increased risk of ototoxicity and nephrotoxicity. Co-administration should be with caution and close monitoring.
Cyclosporine, Cisplatin, Furosemide
Potential increase in nephrotoxicity and ototoxicity.
Other nephrotoxic or ototoxic drugs
Increased risk of adverse effects on kidney and ear function.
Storage
Store in a refrigerator (2°C - 8°C) or at room temperature below 25°C, depending on manufacturer specifications. Protect from light and moisture. Reconstituted solution should be used immediately or within 24 hours if refrigerated.
Overdose
Management is symptomatic and supportive. Teicoplanin is not effectively removed by hemodialysis or peritoneal dialysis. Close monitoring of renal and auditory function is crucial.
Pregnancy & Lactation
Pregnancy category B. Use in pregnancy only if clearly needed. Excreted in breast milk, so caution is advised during breastfeeding or consider alternative feeding.
Side Effects
Contraindications
- Hypersensitivity to Teicoplanin or any glycopeptide antibiotics
- Previous hypersensitivity to vancomycin (potential cross-reactivity)
Drug Interactions
Aminoglycosides (e.g., Gentamicin)
Increased risk of ototoxicity and nephrotoxicity. Co-administration should be with caution and close monitoring.
Cyclosporine, Cisplatin, Furosemide
Potential increase in nephrotoxicity and ototoxicity.
Other nephrotoxic or ototoxic drugs
Increased risk of adverse effects on kidney and ear function.
Storage
Store in a refrigerator (2°C - 8°C) or at room temperature below 25°C, depending on manufacturer specifications. Protect from light and moisture. Reconstituted solution should be used immediately or within 24 hours if refrigerated.
Overdose
Management is symptomatic and supportive. Teicoplanin is not effectively removed by hemodialysis or peritoneal dialysis. Close monitoring of renal and auditory function is crucial.
Pregnancy & Lactation
Pregnancy category B. Use in pregnancy only if clearly needed. Excreted in breast milk, so caution is advised during breastfeeding or consider alternative feeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as per manufacturer instructions (unopened vial).
Availability
Hospitals, pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic versions available, original patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of teicoplanin for various Gram-positive infections, including comparisons with vancomycin.
Lab Monitoring
- Renal function (serum creatinine, BUN)
- Auditory function (audiometry, especially with high doses or co-administration of ototoxic drugs)
- Liver function tests
- Complete blood count (CBC) to monitor for hematological abnormalities
- Teicoplanin serum levels (therapeutic drug monitoring)
Doctor Notes
- Therapeutic drug monitoring (TDM) is recommended, particularly for critically ill patients, those with renal impairment, or when co-administered with nephrotoxic agents.
- Ensure appropriate loading doses for rapid achievement of therapeutic concentrations.
- Monitor renal, hepatic, and auditory function regularly during prolonged therapy.
Patient Guidelines
- Report any signs of kidney problems (e.g., decreased urine output)
- Report any hearing changes (e.g., ringing in ears, hearing loss)
- Inform your doctor about all other medications you are taking
- Do not discontinue treatment early, even if you feel better
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose.
Driving Precautions
Targocid may cause dizziness, which could affect the ability to drive or operate machinery. Patients should be cautious until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration during treatment
- Follow doctor's advice on diet and activity levels
- Avoid self-medication
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Targocid Brand
Other medicines available under the same brand name
