Targocid
Generic Name
Teicoplanin
Manufacturer
Sanofi
Country
France (original developer)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| targocid 400 mg injection | ৳ 1,590.00 | N/A |
Description
Overview of the medicine
Targocid 400 mg Injection contains Teicoplanin, a glycopeptide antibiotic used to treat serious Gram-positive bacterial infections, particularly those resistant to other antibiotics like Methicillin-resistant Staphylococcus aureus (MRSA). It is administered intravenously or intramuscularly.
Uses & Indications
Dosage
Adults
Loading dose: 6 mg/kg every 12 hours for 3 doses, then maintenance dose: 6 mg/kg once daily for most infections. Higher doses (up to 12 mg/kg) may be used for severe infections.
Elderly
No specific dose adjustment based on age alone; adjust based on renal function.
Renal_impairment
Significant dose reduction required based on creatinine clearance. For example, after the loading dose, reduce maintenance dose or extend dosing interval (e.g., every 48 or 72 hours).
How to Take
Targocid is administered via intravenous (IV) infusion (over 30 minutes) or intramuscular (IM) injection. The powder for injection must be reconstituted with the supplied solvent before use.
Mechanism of Action
Teicoplanin inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala precursors, preventing peptidoglycan polymerization. This leads to disruption of the bacterial cell wall and cell death.
Pharmacokinetics
Onset
Rapid for IV administration; therapeutic levels achieved within minutes to hours depending on loading dose.
Excretion
Primarily excreted unchanged by the kidneys (renal excretion) via glomerular filtration. Approximately 80% of an administered dose is excreted in urine within 10 days.
Half life
Approximately 100-170 hours (long half-life, allowing for once-daily dosing after loading).
Absorption
Rapid and complete absorption after intramuscular (IM) administration, reaching peak plasma concentrations within 2-4 hours. Intravenous (IV) administration provides immediate systemic availability.
Metabolism
Minimally metabolized; less than 5% of a dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to teicoplanin or any other glycopeptide antibiotics (e.g., vancomycin)
- Known severe allergic reactions to any excipients
Drug Interactions
Furosemide
Possible increased risk of ototoxicity.
Cyclosporine
Increased risk of nephrotoxicity.
Amphotericin B
Increased risk of nephrotoxicity.
Aminoglycosides (e.g., gentamicin)
Increased risk of nephrotoxicity and ototoxicity. Close monitoring of renal function and hearing is required.
Storage
Store the unopened vials below 25°C. Reconstituted solutions should be used immediately or stored for a limited time (e.g., 24 hours at 2-8°C) as per manufacturer's instructions.
Overdose
Management of teicoplanin overdose involves supportive care and symptomatic treatment. Hemodialysis may be considered to remove teicoplanin from the blood, although its effectiveness is limited due to the large volume of distribution.
Pregnancy & Lactation
Teicoplanin should only be used during pregnancy if clearly necessary and after careful assessment of the benefits and risks, as animal studies have shown potential risks. It is excreted in human milk in small amounts; use during lactation should be with caution.
Side Effects
Contraindications
- Hypersensitivity to teicoplanin or any other glycopeptide antibiotics (e.g., vancomycin)
- Known severe allergic reactions to any excipients
Drug Interactions
Furosemide
Possible increased risk of ototoxicity.
Cyclosporine
Increased risk of nephrotoxicity.
Amphotericin B
Increased risk of nephrotoxicity.
Aminoglycosides (e.g., gentamicin)
Increased risk of nephrotoxicity and ototoxicity. Close monitoring of renal function and hearing is required.
Storage
Store the unopened vials below 25°C. Reconstituted solutions should be used immediately or stored for a limited time (e.g., 24 hours at 2-8°C) as per manufacturer's instructions.
Overdose
Management of teicoplanin overdose involves supportive care and symptomatic treatment. Hemodialysis may be considered to remove teicoplanin from the blood, although its effectiveness is limited due to the large volume of distribution.
Pregnancy & Lactation
Teicoplanin should only be used during pregnancy if clearly necessary and after careful assessment of the benefits and risks, as animal studies have shown potential risks. It is excreted in human milk in small amounts; use during lactation should be with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to the manufacturer's specific product information for exact shelf life and reconstituted solution stability.
Availability
Available in hospitals and retail pharmacies
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Teicoplanin has undergone numerous clinical trials demonstrating its efficacy and safety in various severe Gram-positive bacterial infections, including those resistant to other antibiotics. Ongoing research explores its role in new resistance patterns and combinations.
Lab Monitoring
- Renal function tests (serum creatinine, blood urea nitrogen) regularly, especially in elderly and renally impaired patients
- Auditory function (hearing) monitoring, especially with concomitant ototoxic drugs
- Complete blood count (CBC) to monitor for leukopenia/thrombocytopenia
- Liver function tests (LFTs) if abnormalities are suspected
- Serum teicoplanin concentrations (trough levels) may be monitored to ensure therapeutic efficacy and minimize toxicity, particularly in severe infections or patients with unstable renal function.
Doctor Notes
- Ensure appropriate loading dose to achieve rapid therapeutic levels.
- Monitor serum teicoplanin trough levels, particularly in critically ill patients, those with renal impairment, or on prolonged therapy, to optimize efficacy and prevent toxicity.
- Adjust dose carefully in patients with renal impairment based on creatinine clearance.
- Be vigilant for signs of hypersensitivity reactions, including 'red man syndrome' (though less common than with vancomycin).
Patient Guidelines
- Inform your doctor about any allergies or medical conditions before starting treatment.
- Report any new or worsening side effects immediately.
- Complete the full course of treatment as prescribed, even if you start feeling better, to prevent the infection from returning or developing resistance.
- Ensure adequate hydration during treatment.
- Do not share this medicine with others.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to catch up. Consult your doctor or pharmacist.
Driving Precautions
Teicoplanin may cause dizziness or headaches, which could affect the ability to drive or operate machinery. Patients should be advised to exercise caution until they know how the medicine affects them.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Follow a balanced diet and ensure adequate rest during recovery.
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