Tarlica
Generic Name
Pregabalin 25 mg Tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tarlica 25 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Tarlica 25 mg Tablet contains Pregabalin, which is used to treat neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. It is also used to manage generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose is typically 75 mg/day (25 mg three times daily) for neuropathic pain, gradually titrated up to 150-600 mg/day in 2-3 divided doses based on response and tolerability. For fibromyalgia, start with 75 mg twice daily, increase to 150 mg twice daily within 1 week based on response. For GAD, start with 150 mg/day, may increase to 300-600 mg/day. For seizures, start with 150 mg/day, increased to 300-600 mg/day.
Elderly
Lower initial doses are recommended, with careful titration, especially in patients with impaired renal function. Dosage should be adjusted based on creatinine clearance.
Renal_impairment
Dose adjustment is necessary. For mild impairment (CrCl 30-60 mL/min), reduce total daily dose by 50%. For moderate impairment (CrCl 15-30 mL/min), reduce by 75%. For severe impairment (CrCl <15 mL/min), reduce by 75-90% and administer once daily or every other day.
How to Take
Take orally with or without food. Swallow the tablet whole with water. Do not crush, chew, or break the tablet.
Mechanism of Action
Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. This action leads to its analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Pain relief can be experienced within 1 week of starting treatment for some conditions, with full effect achieved over several weeks. Anxiolytic effects may appear within days.
Excretion
Eliminated primarily by renal excretion as unchanged drug. Renal impairment necessitates dose adjustment.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1 hour. Bioavailability is approximately 90% and is not affected by food.
Metabolism
Pregabalin undergoes negligible metabolism in humans. Approximately 98% is excreted unchanged in the urine.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any of the excipients in the formulation.
Drug Interactions
ACE Inhibitors (e.g., lisinopril, enalapril)
Concomitant use may increase the risk of angioedema, characterized by swelling of the face, lips, tongue, and throat.
Central Nervous System (CNS) Depressants (e.g., opioids, benzodiazepines, alcohol)
May potentiate the sedative and respiratory depressant effects of pregabalin, leading to increased drowsiness, dizziness, and risk of respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management should be supportive and symptomatic, with gastric lavage if recent ingestion. Hemodialysis is an effective method of removing pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Pregabalin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any of the excipients in the formulation.
Drug Interactions
ACE Inhibitors (e.g., lisinopril, enalapril)
Concomitant use may increase the risk of angioedema, characterized by swelling of the face, lips, tongue, and throat.
Central Nervous System (CNS) Depressants (e.g., opioids, benzodiazepines, alcohol)
May potentiate the sedative and respiratory depressant effects of pregabalin, leading to increased drowsiness, dizziness, and risk of respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Management should be supportive and symptomatic, with gastric lavage if recent ingestion. Hemodialysis is an effective method of removing pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Pregabalin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
DGDA approved
Patent Status
Generic available
Clinical Trials
Pregabalin has undergone extensive clinical trials demonstrating its efficacy and safety for various indications, including neuropathic pain, fibromyalgia, and as an adjunctive therapy for seizures.
Lab Monitoring
- No routine specific laboratory monitoring is required for pregabalin. However, renal function should be monitored, especially in elderly patients or those with pre-existing renal impairment.
Doctor Notes
- Advise patients about the potential for central nervous system depressant effects, especially when co-administered with other CNS depressants.
- Emphasize the importance of gradual discontinuation to prevent withdrawal symptoms.
- Monitor for signs of suicidal ideation or unusual behavior changes.
Patient Guidelines
- Do not stop taking Tarlica suddenly, as this may lead to withdrawal symptoms. Consult your doctor for gradual dose reduction.
- Inform your doctor immediately if you experience any unusual side effects, especially mood changes, thoughts of self-harm, or swelling.
- Avoid consuming alcohol while on Tarlica as it can increase drowsiness and dizziness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tarlica may cause dizziness, somnolence, and blurred vision. Patients should be advised not to drive, operate complex machinery, or engage in other potentially dangerous activities until they have gained sufficient experience with Tarlica to gauge whether it adversely affects their abilities.
Lifestyle Advice
- Due to the potential for dizziness and drowsiness, avoid driving or operating heavy machinery until you know how Tarlica affects you.
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, which can complement your treatment.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Tarlica Brand
Other medicines available under the same brand name
