Tarlica
Generic Name
Cariprazine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tarlica 5 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Tarlica 5 mg Tablet contains Cariprazine, an atypical antipsychotic used to treat schizophrenia, bipolar I disorder, and as an adjunctive treatment for major depressive disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 1.5 mg once daily, target range 1.5-6 mg/day. Bipolar Mania: Initial 1.5 mg once daily, target range 3-6 mg/day. Major Depressive Disorder (adjunctive): Initial 1.5 mg once daily, target range 1.5-3 mg/day. Doses are typically titrated.
Elderly
No specific dose adjustment recommended based on age alone, but caution is advised due to potential for increased sensitivity.
Renal_impairment
Mild to moderate renal impairment: No dose adjustment needed. Severe renal impairment (CrCl < 30 mL/min): Not recommended.
How to Take
Orally, once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Cariprazine acts as a partial agonist at dopamine D3 and D2 receptors and serotonin 5-HT1A receptors. It also acts as an antagonist at serotonin 5-HT2B and 5-HT2A receptors, and alpha1A-adrenergic receptors.
Pharmacokinetics
Onset
Clinical effects may be observed within days to weeks.
Excretion
Primarily excreted in urine (about 59%) and feces (about 33%) as metabolites. Less than 1% is excreted as unchanged drug.
Half life
Cariprazine: 2-4 days; Desmethylcariprazine (DCAR): 1-3 weeks; Didesmethylcariprazine (DDCAR): 2-3 weeks.
Absorption
Well absorbed after oral administration, peak plasma concentrations of cariprazine are reached within 3-6 hours. Steady state is achieved within 1 week for cariprazine and 1-2 weeks for its major active metabolites.
Metabolism
Primarily metabolized by CYP3A4 and to a lesser extent by CYP2D6 to its active metabolites, desmethylcariprazine (DCAR) and didesmethylcariprazine (DDCAR).
Side Effects
Contraindications
- Hypersensitivity to cariprazine or any component of the formulation
Drug Interactions
CYP2D6 inhibitors
May increase levels of active metabolites, but no dose adjustment typically required.
Drugs that prolong QT interval
Use with caution due to potential additive effects.
Strong CYP3A4 inducers (e.g., rifampin)
Decrease cariprazine levels; not recommended.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
Increase cariprazine levels; dose reduction may be needed.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms may include sedation, orthostatic hypotension, and extrapyramidal symptoms. Management is supportive, including establishing an airway, monitoring cardiac function, and providing symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to cariprazine or any component of the formulation
Drug Interactions
CYP2D6 inhibitors
May increase levels of active metabolites, but no dose adjustment typically required.
Drugs that prolong QT interval
Use with caution due to potential additive effects.
Strong CYP3A4 inducers (e.g., rifampin)
Decrease cariprazine levels; not recommended.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
Increase cariprazine levels; dose reduction may be needed.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.
Overdose
Symptoms may include sedation, orthostatic hypotension, and extrapyramidal symptoms. Management is supportive, including establishing an airway, monitoring cardiac function, and providing symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
FDA approved
Patent Status
Patented (original formulations until 2030s)
Clinical Trials
Extensive clinical trials have demonstrated efficacy in schizophrenia, bipolar mania, and major depressive disorder. Key trials include studies for acute exacerbation of schizophrenia and maintenance treatment.
Lab Monitoring
- Complete Blood Count (CBC) (monitor for leukopenia/neutropenia)
- Lipid panel (monitor for dyslipidemia)
- Blood glucose (monitor for hyperglycemia)
- Weight (monitor for weight gain)
Doctor Notes
- Educate patients about the risk of akathisia and metabolic changes.
- Monitor for suicidal ideation, especially in younger patients starting treatment.
- Consider lowest effective dose to minimize side effects.
Patient Guidelines
- Do not stop taking this medicine without consulting your doctor.
- Avoid alcohol while on this medication.
- Report any unusual muscle movements or restlessness to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at once.
Driving Precautions
May cause drowsiness, dizziness, or blurred vision. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to manage weight.
- Avoid activities requiring mental alertness until you know how the medicine affects you.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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