Taven-EZ
Generic Name
Rosuvastatin (as calcium) and Ezetimibe
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| taven ez 20 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Taven-EZ 20 mg tablet is a combination medicine used to reduce high cholesterol levels in the blood. It contains Rosuvastatin, an HMG-CoA reductase inhibitor (statin), and Ezetimibe, a cholesterol absorption inhibitor. It works by reducing cholesterol production in the liver and decreasing cholesterol absorption from the intestine.
Uses & Indications
Dosage
Adults
One tablet (Rosuvastatin 20 mg / Ezetimibe 10 mg) orally once daily, with or without food.
Elderly
No specific dose adjustment is generally required, but caution should be exercised in patients with renal impairment.
Renal_impairment
Dose adjustment may be necessary in patients with severe renal impairment (CrCl < 30 mL/min). Consult physician.
How to Take
Take orally once daily, with or without food. It can be taken at any time of day, but it is recommended to take it at the same time each day to maintain consistency.
Mechanism of Action
Rosuvastatin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, thereby reducing hepatic cholesterol synthesis. Ezetimibe inhibits the absorption of cholesterol in the small intestine, leading to a decrease in the delivery of intestinal cholesterol to the liver.
Pharmacokinetics
Onset
Full lipid-lowering effects typically observed within 2-4 weeks.
Excretion
Both primarily excreted in feces (Rosuvastatin: ~90%; Ezetimibe: ~78%).
Half life
Rosuvastatin: Approximately 19 hours. Ezetimibe (active glucuronide): Approximately 22 hours.
Absorption
Rosuvastatin: Approximately 20% absorbed. Ezetimibe: Rapidly absorbed and extensively metabolized to active glucuronide.
Metabolism
Rosuvastatin: Minor metabolism by CYP2C9. Ezetimibe: Primarily by glucuronidation in the intestine and liver.
Side Effects
Contraindications
- •Hypersensitivity to any component of the medication
- •Active liver disease or unexplained persistent elevations of serum transaminases
- •Severe hepatic impairment
- •Pregnancy and lactation
- •Concomitant use with cyclosporine
Drug Interactions
Colchicine
Increased risk of myopathy.
Cyclosporine
Contraindicated due to increased rosuvastatin exposure.
Fibrates / Niacin
Increased risk of myopathy/rhabdomyolysis.
Coumarin anticoagulants (e.g., Warfarin)
May potentiate anticoagulant effect, requiring close INR monitoring.
Protease inhibitors (e.g., Atazanavir/Ritonavir)
Increased rosuvastatin systemic exposure.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be initiated. Monitor liver function and CK levels. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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