Tazox
Generic Name
Cefpodoxime Proxetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tazox 100 mg suspension | ৳ 35.11 | N/A |
Description
Overview of the medicine
Cefpodoxime proxetil is an oral third-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is a prodrug that is de-esterified in the gastrointestinal tract to its active metabolite, cefpodoxime.
Uses & Indications
Dosage
Adults
Adult dosage varies by indication; typically 100-400 mg every 12 hours (as tablets usually). Consult physician.
Elderly
No specific dose adjustment required for elderly patients with normal renal function.
Children
For children 2 months to 12 years: 10 mg/kg/day divided into two doses (every 12 hours) for 5-10 days, not exceeding 400 mg/day.
Renal_impairment
Dosage adjustment is necessary for patients with severe renal impairment (CrCl < 30 mL/min).
How to Take
Shake the bottle well before each use. Administer orally using the provided measuring spoon or cup, with food to enhance absorption.
Mechanism of Action
Cefpodoxime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis and death.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 2-3 hours.
Absorption
Rapidly absorbed and hydrolyzed to cefpodoxime in the intestinal wall. Bioavailability is about 50%.
Metabolism
Prodrug converted to active cefpodoxime. Not significantly metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to cefpodoxime or other cephalosporins
- •History of severe hypersensitivity to penicillin
Drug Interactions
Probenecid
May increase cefpodoxime plasma levels.
Antacids/H2 blockers/PPIs
May decrease cefpodoxime absorption.
Nephrotoxic drugs (e.g., aminoglycosides)
Increased risk of nephrotoxicity.
Storage
Store unopened powder below 30°C. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
Symptoms may include nausea, vomiting, epigastric distress, and diarrhea. Management is primarily supportive; hemodialysis may be useful in severe cases.
Pregnancy & Lactation
Use in pregnancy only if clearly needed after consulting a doctor. Small amounts may pass into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months for unopened powder; 14 days after reconstitution when stored in refrigerator.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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