Tdcef DS
Generic Name
Cefixime
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tdcef ds 200 mg suspension | ৳ 300.00 | N/A |
Description
Overview of the medicine
Tdcef DS (Cefixime) is an oral third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
For adults, the usual dose is 400 mg once daily or 200 mg every 12 hours. For dry syrup (DS), it refers to a pediatric dosage form, typically 100 mg/5 ml. Pediatric doses are usually 8 mg/kg/day, given once daily or in two divided doses.
Elderly
No specific dose adjustment is needed for elderly patients with normal renal function. Dose adjustment is required for elderly patients with renal impairment.
Renal_impairment
Dose adjustment is necessary for patients with creatinine clearance < 60 ml/min. Consult a doctor for specific dosage adjustments.
How to Take
Tdcef DS (Dry Syrup) should be reconstituted with boiled and cooled water as directed. Administer orally, with or without food. Shake well before each use.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentration typically reached within 2-6 hours after oral administration.
Excretion
Primarily excreted unchanged in urine via glomerular filtration and tubular secretion (about 50% of absorbed dose). Some non-renal elimination also occurs.
Half life
Approximately 3-4 hours (for adults with normal renal function).
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent of absorption.
Metabolism
Not extensively metabolized in the body. A small portion may be metabolized to inactive compounds.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime administration.
Nephrotoxic drugs
Concomitant use with other nephrotoxic drugs (e.g., aminoglycosides) may increase the risk of renal toxicity.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR). Monitor coagulation parameters.
Storage
Store dry powder below 30°C, protected from light and moisture. Keep reconstituted suspension refrigerated (2-8°C) and discard after 7-14 days.
Overdose
Gastric lavage may be indicated. Symptomatic and supportive treatment is recommended. Hemodialysis and peritoneal dialysis do not remove cefixime from the body to a significant extent.
Pregnancy & Lactation
Pregnancy Category B. Cefixime crosses the placenta. Use in pregnancy only if clearly needed. Excreted in low amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Increased carbamazepine levels have been reported with concomitant cefixime administration.
Nephrotoxic drugs
Concomitant use with other nephrotoxic drugs (e.g., aminoglycosides) may increase the risk of renal toxicity.
Oral Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR). Monitor coagulation parameters.
Storage
Store dry powder below 30°C, protected from light and moisture. Keep reconstituted suspension refrigerated (2-8°C) and discard after 7-14 days.
Overdose
Gastric lavage may be indicated. Symptomatic and supportive treatment is recommended. Hemodialysis and peritoneal dialysis do not remove cefixime from the body to a significant extent.
Pregnancy & Lactation
Pregnancy Category B. Cefixime crosses the placenta. Use in pregnancy only if clearly needed. Excreted in low amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted dry powder). Reconstituted suspension is stable for 7-14 days when refrigerated.
Availability
Available in pharmacies and hospitals
Approval Status
DGDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across pediatric and adult populations.
Lab Monitoring
- Periodic monitoring of renal function is advised during prolonged therapy.
- Monitor coagulation parameters (INR/PT) in patients concomitantly receiving oral anticoagulants.
Doctor Notes
- Assess bacterial susceptibility before initiation of therapy.
- Adjust dose in patients with significant renal impairment.
- Counsel patients on completing the full course to prevent resistance.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Do not share this medication with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid driving.
Lifestyle Advice
- Maintain adequate hydration.
- Consider taking probiotics to help prevent antibiotic-associated diarrhea.
- Avoid alcohol consumption during the course of treatment, as it may worsen gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.