Telfast
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Sanofi
Country
France (originator), Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telfast 120 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Telfast 120 mg tablet contains Fexofenadine Hydrochloride, a non-drowsy antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
120 mg once daily.
Elderly
No specific dose adjustment is generally required.
Renal_impairment
For patients with moderate to severe renal impairment (creatinine clearance < 80 mL/min), the recommended starting dose is 60 mg once daily.
How to Take
Telfast 120 mg tablets are for oral use. They can be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It inhibits the release of histamine from mast cells, thereby reducing the symptoms of allergic reactions without significant sedation.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted unchanged in feces (approximately 80%) and urine (approximately 11%).
Half life
Approximately 14.4 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1-3 hours.
Metabolism
Minimally metabolized; about 5% of the total dose undergoes hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of the excipients.
- Children under 12 years for 120 mg strength (for specific indications/age groups, consult prescribing information).
Drug Interactions
Erythromycin and Ketoconazole
Concomitant use with erythromycin or ketoconazole has been shown to increase fexofenadine plasma levels, although this does not appear to increase adverse effects.
Antacids (containing aluminum and magnesium)
Co-administration with aluminum- and magnesium-containing antacids may reduce the absorption of fexofenadine. It is recommended to separate administration times by about 2 hours.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, dry mouth, and nausea. Management is symptomatic and supportive, including gastric lavage or activated charcoal if appropriate.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk in small amounts; use with caution during lactation and only if clearly needed after consulting a doctor.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of the excipients.
- Children under 12 years for 120 mg strength (for specific indications/age groups, consult prescribing information).
Drug Interactions
Erythromycin and Ketoconazole
Concomitant use with erythromycin or ketoconazole has been shown to increase fexofenadine plasma levels, although this does not appear to increase adverse effects.
Antacids (containing aluminum and magnesium)
Co-administration with aluminum- and magnesium-containing antacids may reduce the absorption of fexofenadine. It is recommended to separate administration times by about 2 hours.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, dry mouth, and nausea. Management is symptomatic and supportive, including gastric lavage or activated charcoal if appropriate.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk in small amounts; use with caution during lactation and only if clearly needed after consulting a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, consult package for exact date.
Availability
Pharmacies, hospitals
Approval Status
FDA Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of fexofenadine for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria, showing significant symptom relief with a favorable tolerability profile.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients taking fexofenadine.
Doctor Notes
- Advise patients about potential drug-food interactions with fruit juices.
- Reassure patients about the non-sedating nature of fexofenadine.
- Consider dose adjustment in patients with moderate to severe renal impairment.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with fruit juices (grapefruit, orange, apple).
- Consult your doctor if symptoms persist or worsen.
- Inform your doctor or pharmacist about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally considered non-drowsy. However, individual responses to medication can vary. Patients should exercise caution when driving or operating machinery until they know how Telfast affects them.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain a healthy lifestyle, including adequate hydration and sleep, to support overall well-being.
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