Telide
Generic Name
Azithromycin
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telide 500 mg tablet | ৳ 35.00 | ৳ 245.00 |
Description
Overview of the medicine
Telide 500 mg Tablet contains Azithromycin, a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
Typical dose for most infections is 500 mg once daily for 3 days, or 500 mg once on day 1 followed by 250 mg once daily for 4 days. For STIs, a single 1 g dose may be used.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment. Caution is advised for severe renal impairment (CrCl <10 mL/min) due to lack of data.
How to Take
Telide 500 mg Tablet can be taken with or without food. To minimize gastrointestinal upset, it may be taken with food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. It is generally considered bacteriostatic but can be bactericidal at high concentrations or against highly susceptible organisms.
Pharmacokinetics
Onset
Peak plasma concentrations are reached within 2-3 hours.
Excretion
Mainly excreted unchanged in the bile, with a small amount excreted in urine (approx. 6%).
Half life
Terminal elimination half-life of 2-4 days (40-68 hours).
Absorption
Well absorbed from the gastrointestinal tract; bioavailability is approximately 37% and is slightly reduced by food.
Metabolism
Primarily metabolized in the liver by N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to Azithromycin, Erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin serum concentrations; monitor for side effects.
Antacids containing aluminum or magnesium
Decreased peak plasma levels of azithromycin; take azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., antiarrhythmics, antipsychotics)
Increased risk of QT prolongation and cardiac arrhythmias.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures as clinically indicated. Gastric lavage and supportive care may be necessary.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Azithromycin, Erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use
Drug Interactions
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin serum concentrations; monitor for side effects.
Antacids containing aluminum or magnesium
Decreased peak plasma levels of azithromycin; take azithromycin at least 1 hour before or 2 hours after antacids.
QT-prolonging drugs (e.g., antiarrhythmics, antipsychotics)
Increased risk of QT prolongation and cardiac arrhythmias.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures as clinically indicated. Gastric lavage and supportive care may be necessary.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Azithromycin's efficacy and safety for its approved indications. Studies have demonstrated its effectiveness against various bacterial pathogens and its favorable pharmacokinetic profile allowing for short treatment courses.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment)
- Renal function tests (in severe renal impairment)
- ECG monitoring (in patients at risk of QT prolongation)
Doctor Notes
- Confirm bacterial infection before prescribing.
- Advise patients to complete the full course.
- Counsel on potential QT prolongation risks, especially in high-risk patients.
- Be aware of potential drug interactions, particularly with anticoagulants and QT-prolonging agents.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve, to prevent resistance.
- Do not share this medication with others.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Seek medical attention if you experience severe diarrhea, rash, or signs of liver problems.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Telide 500 mg Tablet usually does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration during antibiotic treatment.
- Avoid alcohol consumption as it may worsen gastrointestinal side effects.
- Get sufficient rest to aid recovery.
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Global Brand Names
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