Telsar
Generic Name
Telmisartan
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telsar 40 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Telsar 40 mg Tablet contains Telmisartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events like heart attack and stroke in patients at high risk.
Uses & Indications
Dosage
Adults
The usual recommended dose is 40 mg once daily. The maximum dose is 80 mg once daily.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. For severe renal impairment or hemodialysis patients, careful monitoring is advised.
How to Take
Take Telsar 40 mg Tablet orally once daily with or without food. Swallow the tablet whole with water. Do not chew or crush it. It is recommended to take the tablet at approximately the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues (e.g., vascular smooth muscle, adrenal gland). This blockade inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased blood pressure, and reduced sodium and water retention.
Pharmacokinetics
Onset
Onset of antihypertensive effect within 3 hours; maximal reduction in blood pressure generally achieved after 4-8 weeks of therapy.
Excretion
Almost exclusively excreted in the feces, mainly as unchanged drug (>97%) and a small amount as glucuronide conjugate. Less than 1% is excreted in the urine.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is dose-dependent (~42% for 40 mg, ~58% for 80 mg). Peak plasma concentrations occur 0.5-1 hour after oral administration.
Metabolism
Primarily metabolized by conjugation to form an acylglucuronide, which is pharmacologically inactive. Not metabolized by cytochrome P450 system.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any component of the tablet.
- Pregnancy (especially during the second and third trimesters).
- Lactation (breastfeeding).
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m²).
Drug Interactions
Digoxin
Increased plasma digoxin concentration has been reported with concomitant use of Telmisartan.
Lithium
Increased serum lithium concentrations and toxicity have been reported with concomitant use of ARBs.
Ramipril or Aliskiren
Concomitant use is associated with an increased risk of hypotension, hyperkalemia, and decreased renal function, especially in diabetics or those with renal impairment.
Diuretics and other Antihypertensives
May enhance the hypotensive effect of Telmisartan.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
May reduce the antihypertensive effect of Telmisartan and increase the risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data are available regarding overdose in humans. The most likely manifestations would be hypotension (low blood pressure) and tachycardia; bradycardia could also occur. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Telsar is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal injury or death. It is also not recommended during lactation, as it is unknown whether Telmisartan is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any component of the tablet.
- Pregnancy (especially during the second and third trimesters).
- Lactation (breastfeeding).
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m²).
Drug Interactions
Digoxin
Increased plasma digoxin concentration has been reported with concomitant use of Telmisartan.
Lithium
Increased serum lithium concentrations and toxicity have been reported with concomitant use of ARBs.
Ramipril or Aliskiren
Concomitant use is associated with an increased risk of hypotension, hyperkalemia, and decreased renal function, especially in diabetics or those with renal impairment.
Diuretics and other Antihypertensives
May enhance the hypotensive effect of Telmisartan.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
May reduce the antihypertensive effect of Telmisartan and increase the risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited data are available regarding overdose in humans. The most likely manifestations would be hypotension (low blood pressure) and tachycardia; bradycardia could also occur. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Telsar is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal injury or death. It is also not recommended during lactation, as it is unknown whether Telmisartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
FDA approved (Telmisartan), DGDA approved
Patent Status
Generic available
Clinical Trials
Telmisartan has been extensively studied in various clinical trials (e.g., ONTARGET, TRANSCEND) demonstrating its efficacy in blood pressure reduction and cardiovascular risk management.
Lab Monitoring
- Serum potassium levels (especially in patients with renal impairment or those on potassium-sparing diuretics)
- Renal function (serum creatinine, BUN)
Doctor Notes
- Advise patients to avoid potassium supplements or salt substitutes containing potassium without consulting.
- Caution in patients with hepatic impairment, as Telmisartan is primarily eliminated via bile.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor, even if you feel well.
- Do not stop taking Telsar without consulting your doctor.
- Monitor your blood pressure regularly at home.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Telsar may cause dizziness or drowsiness in some individuals. Patients should be cautioned about operating machinery or driving until they know how Telsar affects them.
Lifestyle Advice
- Adopt a low-sodium diet and limit processed foods.
- Engage in regular physical activity as advised by your doctor.
- Maintain a healthy weight.
- Avoid smoking and limit alcohol consumption.
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