Telsar
Generic Name
Telmisartan
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| telsar 80 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Telsar 80 mg Tablet contains Telmisartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events in certain high-risk patients.
Uses & Indications
Dosage
Adults
Hypertension: Initial 40 mg once daily, adjusted to maximum 80 mg once daily. Cardiovascular risk reduction: 80 mg once daily.
Elderly
No dosage adjustment generally required based on age alone.
Renal_impairment
No dosage adjustment for mild to moderate renal impairment. For severe impairment or dialysis, lower initial doses and careful monitoring may be considered.
How to Take
Administer orally once daily with or without food. It is recommended to take the tablet at about the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor, primarily located in vascular smooth muscle and the adrenal gland. This inhibits the vasoconstricting and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased blood pressure, and reduced sodium and water retention.
Pharmacokinetics
Onset
Antihypertensive effect begins within 3 hours, maximum effect usually seen within 4-8 weeks.
Excretion
Mainly excreted unchanged in feces via biliary excretion (>97%).
Half life
Approximately 20-24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with absolute bioavailability of about 50% for 40 mg and 42% for 160 mg. Food slightly reduces bioavailability.
Metabolism
Minimally metabolized; primarily conjugated to its glucuronide.
Side Effects
Contraindications
- Hypersensitivity to telmisartan or any component of the tablet
- Pregnancy (especially second and third trimesters)
- Lactation
- Biliary obstructive disorders
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²)
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin have been observed; monitor digoxin levels.
Lithium
Increased serum lithium concentrations and toxicity have been reported during concomitant administration with ARBs. Monitor lithium levels.
Aliskiren
Concomitant use contraindicated in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²).
Diuretics (e.g., Furosemide)
May enhance the hypotensive effect, increasing risk of symptomatic hypotension.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effect of telmisartan and potentially worsen renal function.
Potassium-sparing diuretics (e.g., Spironolactone) or Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension, dizziness, tachycardia, and bradycardia. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated during the second and third trimesters of pregnancy due to risk of fetal harm and death (Black Box Warning). Not recommended during the first trimester. Contraindicated during lactation due to unknown excretion in human milk and potential for adverse effects on nursing infant.
Side Effects
Contraindications
- Hypersensitivity to telmisartan or any component of the tablet
- Pregnancy (especially second and third trimesters)
- Lactation
- Biliary obstructive disorders
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²)
Drug Interactions
Digoxin
Increased plasma concentrations of digoxin have been observed; monitor digoxin levels.
Lithium
Increased serum lithium concentrations and toxicity have been reported during concomitant administration with ARBs. Monitor lithium levels.
Aliskiren
Concomitant use contraindicated in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²).
Diuretics (e.g., Furosemide)
May enhance the hypotensive effect, increasing risk of symptomatic hypotension.
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effect of telmisartan and potentially worsen renal function.
Potassium-sparing diuretics (e.g., Spironolactone) or Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension, dizziness, tachycardia, and bradycardia. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Contraindicated during the second and third trimesters of pregnancy due to risk of fetal harm and death (Black Box Warning). Not recommended during the first trimester. Contraindicated during lactation due to unknown excretion in human milk and potential for adverse effects on nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established Telmisartan's efficacy in hypertension and cardiovascular risk reduction, including the ONTARGET and TRANSCEND studies.
Lab Monitoring
- Blood pressure monitoring
- Serum potassium levels (especially in patients with renal impairment or on potassium-sparing diuretics)
- Renal function (BUN, creatinine) periodically
- Liver function tests (if hepatic impairment suspected)
Doctor Notes
- Counsel patients on potential for dizziness and importance of consistent daily dosing.
- Monitor BP and serum potassium regularly, especially when initiating therapy or adjusting dose.
- Avoid in pregnancy; ensure effective contraception for women of childbearing potential.
Patient Guidelines
- Take as directed by your doctor, preferably at the same time each day.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any signs of swelling of the face, lips, tongue, or throat immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness, especially at the start of treatment or when the dose is increased. Exercise caution when driving or operating machinery until you know how Telsar affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Quit smoking if applicable.
- Monitor blood pressure regularly at home if advised.
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