Temcox
Generic Name
Temcoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| temcox 120 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Temcox 120 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) primarily used for pain relief and reducing inflammation. It selectively inhibits cyclooxygenase-2 (COX-2) enzyme.
Uses & Indications
Dosage
Adults
The usual recommended dose is 120 mg once daily, taken orally. Maximum daily dose should not exceed 120 mg.
Elderly
No specific dose adjustment is usually required for elderly patients, but caution is advised due to potential age-related decrease in renal or hepatic function. Consider starting with a lower dose.
Renal_impairment
For mild to moderate renal impairment, no dose adjustment is generally needed. For severe renal impairment, use with caution and consider dose reduction; not recommended in end-stage renal disease.
How to Take
Take the tablet orally, with or without food. Swallow whole with a glass of water. Do not crush or chew.
Mechanism of Action
Temcoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins involved in inflammation, pain, and fever. By inhibiting COX-2, it reduces these symptoms with a potentially lower risk of gastrointestinal side effects compared to non-selective NSAIDs.
Pharmacokinetics
Onset
Approximately 1-2 hours for significant pain relief.
Excretion
Excreted predominantly via urine (approximately 50%) and feces (approximately 25%) as metabolites.
Half life
About 8-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 2-3 hours.
Metabolism
Primarily metabolized in the liver, mainly via cytochrome P450 (CYP2C9) enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Temcoxib or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure (NYHA Class III-IV)
- Severe renal impairment (CrCl <30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
- History of cerebrovascular disease or uncontrolled hypertension
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate plasma concentrations, enhancing its toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Warfarin and other anticoagulants
Increased risk of bleeding.
CYP2C9 inhibitors (e.g., Fluconazole)
May increase Temcoxib plasma levels.
Diuretics (e.g., Furosemide, Thiazide diuretics)
May reduce the natriuretic effect of diuretics and increase the risk of renal failure.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
May diminish the antihypertensive effect and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding can occur. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is symptomatic and supportive. There is no specific antidote. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid use in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction. Use with caution in first and second trimesters only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk; avoid during breastfeeding or discontinue the drug, considering the importance of the drug to the mother.
Side Effects
Contraindications
- Known hypersensitivity to Temcoxib or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure (NYHA Class III-IV)
- Severe renal impairment (CrCl <30 mL/min)
- Severe hepatic impairment
- Third trimester of pregnancy
- History of cerebrovascular disease or uncontrolled hypertension
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity.
Methotrexate
May increase methotrexate plasma concentrations, enhancing its toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Warfarin and other anticoagulants
Increased risk of bleeding.
CYP2C9 inhibitors (e.g., Fluconazole)
May increase Temcoxib plasma levels.
Diuretics (e.g., Furosemide, Thiazide diuretics)
May reduce the natriuretic effect of diuretics and increase the risk of renal failure.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
May diminish the antihypertensive effect and increase the risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding can occur. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is symptomatic and supportive. There is no specific antidote. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid use in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction. Use with caution in first and second trimesters only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk; avoid during breastfeeding or discontinue the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
DGDA Approved
Patent Status
Off-patent (Generic available)
Clinical Trials
Temcoxib has undergone various clinical trials demonstrating its efficacy and safety in the treatment of pain and inflammation, typical for selective COX-2 inhibitors.
Lab Monitoring
- Monitor renal function (serum creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or those on diuretics.
- Monitor liver function tests (ALT, AST) periodically, especially in patients with hepatic impairment.
- Monitor blood pressure regularly, particularly at the initiation of treatment and during long-term use.
- Periodically monitor complete blood count (CBC) in patients receiving long-term treatment.
Doctor Notes
- Before prescribing, assess patient's cardiovascular risk factors, history of GI events, and renal function.
- Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Counsel patients on potential cardiovascular and gastrointestinal risks associated with NSAID use.
Patient Guidelines
- Take Temcoxib exactly as prescribed by your doctor. Do not exceed the recommended dose.
- Inform your doctor if you have a history of heart disease, high blood pressure, stomach ulcers, or kidney problems.
- Report any unusual bleeding, persistent stomach pain, dark stools, or swelling to your doctor immediately.
- Do not take other NSAIDs or aspirin concurrently without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Temcoxib may cause dizziness or drowsiness in some individuals. If you experience these side effects, avoid driving or operating heavy machinery until you know how the medication affects you.
Lifestyle Advice
- Avoid excessive alcohol consumption while on Temcoxib, as it may increase the risk of stomach irritation and bleeding.
- Maintain a balanced diet and stay hydrated.
- Engage in light physical activity if appropriate for your condition.
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