Temcox
Generic Name
Etoricoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| temcox 90 mg tablet | ৳ 11.50 | ৳ 115.00 |
Description
Overview of the medicine
Temcox 90 mg Tablet contains Etoricoxib, a selective COX-2 inhibitor, belonging to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis.
Uses & Indications
Dosage
Adults
For Rheumatoid Arthritis/Ankylosing Spondylitis: 60 mg or 90 mg once daily. For Acute pain/Primary dysmenorrhea: 90 mg once daily for a maximum of 5 days. For Acute gouty arthritis: 120 mg once daily for a maximum of 8 days.
Elderly
No dose adjustment generally required, but caution is advised due to increased risk of adverse effects.
Renal_impairment
Mild to moderate (CrCl 30-80 mL/min): No dose adjustment. Severe (CrCl <30 mL/min): Not recommended.
How to Take
Temcox 90 mg Tablet should be taken orally, with or without food. Taking it with food may help reduce gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins that cause pain, inflammation, and fever. By inhibiting COX-2, it reduces these symptoms without significantly affecting COX-1, which is involved in protecting the stomach lining.
Pharmacokinetics
Onset
Analgesic effect typically within 30-45 minutes.
Excretion
Primarily via urine (70%) and feces (20%) as metabolites.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations are reached in approximately 1 hour after oral administration.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 enzymes (CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Etoricoxib or any excipients.
- Active peptic ulceration or gastrointestinal (GI) bleeding.
- Severe hepatic dysfunction.
- Severe renal disease (creatinine clearance <30 mL/min).
- Congestive heart failure (NYHA II-IV).
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.
Drug Interactions
Lithium
May increase plasma lithium levels and toxicity.
Warfarin
May increase INR and risk of bleeding.
Diuretics
May reduce diuretic and antihypertensive effects.
Methotrexate
May increase methotrexate concentrations and toxicity.
ACE Inhibitors/ARBs
May reduce antihypertensive effect and increase risk of renal impairment.
Oral Contraceptives
May increase plasma concentrations of ethinylestradiol.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal disturbances, renal toxicity, and cardiovascular events. Management is symptomatic and supportive; there is no specific antidote for Etoricoxib overdose. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus including premature closure of the ductus arteriosus and renal dysfunction. Avoid during lactation as Etoricoxib is excreted in breast milk and may harm the nursing infant.
Side Effects
Contraindications
- Hypersensitivity to Etoricoxib or any excipients.
- Active peptic ulceration or gastrointestinal (GI) bleeding.
- Severe hepatic dysfunction.
- Severe renal disease (creatinine clearance <30 mL/min).
- Congestive heart failure (NYHA II-IV).
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.
Drug Interactions
Lithium
May increase plasma lithium levels and toxicity.
Warfarin
May increase INR and risk of bleeding.
Diuretics
May reduce diuretic and antihypertensive effects.
Methotrexate
May increase methotrexate concentrations and toxicity.
ACE Inhibitors/ARBs
May reduce antihypertensive effect and increase risk of renal impairment.
Oral Contraceptives
May increase plasma concentrations of ethinylestradiol.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal disturbances, renal toxicity, and cardiovascular events. Management is symptomatic and supportive; there is no specific antidote for Etoricoxib overdose. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus including premature closure of the ductus arteriosus and renal dysfunction. Avoid during lactation as Etoricoxib is excreted in breast milk and may harm the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, as indicated on the packaging.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, patent expired for active ingredient
Clinical Trials
Etoricoxib has undergone extensive clinical trials demonstrating its efficacy and safety profile for various pain and inflammatory conditions, leading to its global approval.
Lab Monitoring
- Liver function tests (especially with long-term use)
- Renal function tests (e.g., creatinine, BUN)
- Blood pressure monitoring
- Complete blood count (CBC) for signs of GI bleeding
Doctor Notes
- Assess cardiovascular risk factors (e.g., hypertension, hyperlipidemia, diabetes, smoking) before prescribing Etoricoxib, particularly for long-term use.
- Monitor blood pressure regularly in all patients receiving Etoricoxib, especially during the initial weeks of treatment.
- Use the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals to minimize potential risks.
Patient Guidelines
- Take Temcox 90 mg Tablet exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual bleeding, severe stomach pain, chest pain, or swelling immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Temcox 90 mg Tablet may cause dizziness, vertigo, or drowsiness in some individuals. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and engage in regular, moderate exercise, as advised by your healthcare provider.
- Avoid alcohol consumption while taking this medication as it may increase the risk of gastrointestinal bleeding.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, you are taking.
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