Tempanil
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tempanil 500 mg tablet | ৳ 1.20 | N/A |
Description
Overview of the medicine
Tempanil (Paracetamol) is a commonly used medication for relieving mild to moderate pain and reducing fever. It works by blocking the production of certain natural substances in the body that cause pain and fever.
Uses & Indications
Dosage
Adults
Oral: 500 mg to 1000 mg every 4-6 hours as needed. Maximum 4000 mg in 24 hours.
Elderly
Similar to adult dosage, but caution should be exercised in those with impaired renal or hepatic function. Dosing interval may need to be extended.
Renal_impairment
If creatinine clearance is 10-50 mL/min, administer every 6 hours. If less than 10 mL/min, administer every 8 hours.
How to Take
Tempanil tablets can be taken orally with or without food. It is recommended to take them with a glass of water.
Mechanism of Action
Paracetamol primarily acts by inhibiting prostaglandin synthesis in the central nervous system (CNS), leading to analgesic and antipyretic effects. It has minimal anti-inflammatory activity.
Pharmacokinetics
Onset
30-60 minutes for analgesic/antipyretic effects.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1-4 hours in adults; slightly longer in neonates and in patients with hepatic or renal impairment.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations occur within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI), which is normally detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Concurrent use with alcohol increases the risk of hepatotoxicity.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding.
Certain anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine)
May increase the risk of hepatotoxicity due to induction of hepatic enzymes.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe liver damage, possibly fatal. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite. Immediate medical attention is crucial. Treatment involves gastric lavage and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but it is always advisable to consult a healthcare professional before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Concurrent use with alcohol increases the risk of hepatotoxicity.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding.
Certain anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine)
May increase the risk of hepatotoxicity due to induction of hepatic enzymes.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe liver damage, possibly fatal. Symptoms may include nausea, vomiting, abdominal pain, and loss of appetite. Immediate medical attention is crucial. Treatment involves gastric lavage and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but it is always advisable to consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in all pharmacies and drug stores nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (Generic)
WHO Essential Medicine
YesClinical Trials
Paracetamol has been extensively studied for decades, and its efficacy and safety are well-established through numerous clinical trials and widespread clinical use.
Lab Monitoring
- Liver function tests (LFTs) in cases of prolonged use, high doses, or suspected overdose.
- Renal function tests may be considered in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients on the importance of not exceeding the maximum daily dose (4g in 24 hours) to prevent hepatotoxicity.
- Counsel patients to check other OTC products for acetaminophen content to avoid inadvertent overdose.
- Be cautious in patients with pre-existing liver disease or chronic alcohol use.
Patient Guidelines
- Do not exceed the recommended dose of 4000 mg (8 tablets of 500 mg) in 24 hours.
- Avoid taking other medications containing paracetamol simultaneously.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Tempanil is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid these activities.
Lifestyle Advice
- Stay hydrated, especially when having a fever.
- Avoid alcohol consumption while taking paracetamol, as it increases the risk of liver damage.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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