Tetracomb
Generic Name
Betamethasone Valerate + Gentamicin Sulfate + Clioquinol + Tolnaftate
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tetracomb cream | ৳ 40.00 | N/A |
Description
Overview of the medicine
Tetracomb Cream is a combination topical medication containing a corticosteroid (Betamethasone Valerate), an aminoglycoside antibiotic (Gentamicin Sulfate), an antiseptic/antifungal (Clioquinol), and an antifungal (Tolnaftate). It is used to treat various inflammatory skin conditions complicated by bacterial and fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area 2-3 times daily, or as directed by physician. Treatment duration should generally not exceed 7-14 days.
Elderly
No specific dosage adjustments required; use with caution for prolonged periods due to potentially thinner skin.
Renal_impairment
No dosage adjustment needed for topical application due to minimal systemic absorption.
How to Take
For topical dermatological use only. Apply thinly and gently rub into the affected area. Wash hands before and after application. Avoid contact with eyes, mouth, and other mucous membranes.
Mechanism of Action
Betamethasone Valerate acts as a potent corticosteroid, reducing inflammation, itching, and vasoconstriction. Gentamicin Sulfate is a broad-spectrum antibiotic that inhibits bacterial protein synthesis. Clioquinol has antibacterial and antifungal properties, disrupting microbial cell functions. Tolnaftate is an antifungal agent that inhibits fungal growth by interfering with ergosterol synthesis.
Pharmacokinetics
Onset
Relief of symptoms typically begins within a few days of initiation.
Excretion
Excreted primarily via urine if significant systemic absorption occurs. Otherwise, locally removed by skin shedding.
Half life
Not precisely determined for topical application due to minimal systemic absorption.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with skin damage, inflammation, or occlusive dressings.
Metabolism
Absorbed corticosteroids are metabolized in the liver. Gentamicin and clioquinol undergo minimal metabolism when topically applied.
Side Effects
Contraindications
- Hypersensitivity to any component of the cream
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis
- Vaccinia, syphilitic skin lesions
- Fungal infections not susceptible to Tolnaftate/Clioquinol
Drug Interactions
None specific
Minimal systemic absorption makes clinically significant drug interactions unlikely with topical application.
Storage
Store below 30°C in a dry place, away from direct light and heat. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged or excessive use may lead to systemic effects of corticosteroids, such as Cushing's syndrome, hyperglycemia, and HPA axis suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use with caution during pregnancy and lactation, only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to any component of the cream
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin, acne vulgaris, rosacea, perioral dermatitis
- Vaccinia, syphilitic skin lesions
- Fungal infections not susceptible to Tolnaftate/Clioquinol
Drug Interactions
None specific
Minimal systemic absorption makes clinically significant drug interactions unlikely with topical application.
Storage
Store below 30°C in a dry place, away from direct light and heat. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Prolonged or excessive use may lead to systemic effects of corticosteroids, such as Cushing's syndrome, hyperglycemia, and HPA axis suppression. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use with caution during pregnancy and lactation, only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved in Bangladesh
Patent Status
Off-patent
Clinical Trials
This combination of well-established active ingredients has been extensively studied for its individual components. Specific clinical trials for this particular brand combination focus on bioequivalence and safety.
Lab Monitoring
- No routine laboratory monitoring is typically required for topical use.
Doctor Notes
- Emphasize limited duration of use (max 2 weeks, especially on face/children).
- Educate patients on signs of local side effects and systemic absorption.
Patient Guidelines
- Use only as directed by your doctor; do not exceed the recommended duration.
- Do not apply to open wounds, eyes, or mucous membranes.
- Avoid covering the treated area with occlusive dressings unless specifically instructed by your doctor.
- Do not use on the face or in skin folds for prolonged periods.
- Inform your doctor if your condition worsens or does not improve after 7-14 days.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember, unless it is almost time for your next dose. Do not apply a double dose to make up for a missed one.
Driving Precautions
Tetracomb Cream is for topical use and is unlikely to affect your ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent further infections.
- Avoid scratching the affected area to prevent skin damage and secondary infections.
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Global Brand Names
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