Tetracomb
Generic Name
Tetracycline, Neomycin, Nystatin, Triamcinolone Acetonide Ointment
Manufacturer
Square Pharmaceuticals Ltd. (example for Bangladesh)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tetracomb ointment | ৳ 40.00 | N/A |
Description
Overview of the medicine
Tetracomb Ointment is a topical preparation containing a combination of an antibiotic (Tetracycline, Neomycin), an antifungal (Nystatin), and a corticosteroid (Triamcinolone Acetonide). It is used for treating mixed bacterial, fungal, and inflammatory skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area 2-3 times daily. Gently rub in. Treatment should not exceed 7-10 days without medical supervision.
Elderly
No specific dosage adjustments required; use with caution due to thinner skin.
Renal_impairment
Topical use generally does not require dosage adjustment due to minimal systemic absorption.
How to Take
For external use only. Wash hands before and after application. Apply a thin film to the affected skin area and gently massage until it disappears. Do not cover with occlusive dressings unless directed by a physician.
Mechanism of Action
Tetracycline and Neomycin inhibit bacterial protein synthesis, Nystatin binds to ergosterol in fungal cell membranes disrupting permeability, and Triamcinolone Acetonide exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by inducing phospholipase A2 inhibitory proteins.
Pharmacokinetics
Onset
Local effects (anti-inflammatory, antimicrobial) typically within hours to a few days.
Excretion
Systemically absorbed Triamcinolone is excreted in urine. Neomycin and Nystatin are primarily excreted unchanged in feces if taken orally, but topical absorption leads to urinary excretion for small amounts. Tetracycline is excreted via kidneys and bile.
Half life
Systemic half-life for components is not highly relevant for topical use, but if absorbed, Triamcinolone has a plasma half-life of 2-5 hours, Nystatin and Neomycin are poorly absorbed, Tetracycline's systemic half-life is around 6-11 hours.
Absorption
Minimal systemic absorption through intact skin. Absorption increases with inflammation, occlusion, and prolonged use, especially in large areas or damaged skin.
Metabolism
Triamcinolone is metabolized primarily in the liver. Neomycin, Nystatin, and Tetracycline, if absorbed systemically, undergo minimal to some metabolism.
Side Effects
Contraindications
- Hypersensitivity to any component of the preparation
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin
- Perioral dermatitis and rosacea
- Children under 2 years of age
Drug Interactions
Other topical preparations
Avoid concurrent use of other topical corticosteroids or antibiotics on the same area to prevent altered absorption or additive effects.
None significant for systemic drugs
Due to minimal systemic absorption, clinically significant interactions with systemically administered drugs are unlikely.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical use. Chronic excessive use, especially over large areas or under occlusive dressings, may lead to systemic corticosteroid effects (e.g., Cushing's syndrome) or antibiotic/antifungal side effects. Treatment is symptomatic and supportive; gradual withdrawal of corticosteroids may be necessary.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus or infant. Avoid extensive use or application to large body areas.
Side Effects
Contraindications
- Hypersensitivity to any component of the preparation
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculosis of the skin
- Perioral dermatitis and rosacea
- Children under 2 years of age
Drug Interactions
Other topical preparations
Avoid concurrent use of other topical corticosteroids or antibiotics on the same area to prevent altered absorption or additive effects.
None significant for systemic drugs
Due to minimal systemic absorption, clinically significant interactions with systemically administered drugs are unlikely.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical use. Chronic excessive use, especially over large areas or under occlusive dressings, may lead to systemic corticosteroid effects (e.g., Cushing's syndrome) or antibiotic/antifungal side effects. Treatment is symptomatic and supportive; gradual withdrawal of corticosteroids may be necessary.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus or infant. Avoid extensive use or application to large body areas.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities in various countries (e.g., DGDA in Bangladesh)
Patent Status
Generic available (Patent expired)
Clinical Trials
Clinical trials have established the efficacy and safety of its individual components and similar combinations for various dermatological conditions. Specific trials for 'Tetracomb Ointment' brand might exist but are not broadly publicised.
Lab Monitoring
- Not routinely required for topical application. If prolonged or extensive use leads to systemic absorption, monitoring of adrenal function (e.g., plasma cortisol) might be considered.
Doctor Notes
- Emphasize short-term use to minimize corticosteroid side effects.
- Counsel patients on proper application technique.
- Monitor for signs of secondary infection or lack of response.
Patient Guidelines
- Use exactly as directed by your doctor.
- Do not use for longer than prescribed.
- Avoid contact with eyes, nose, and mouth.
- Do not apply to large areas of the body or under bandages unless advised by your doctor.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose.
Driving Precautions
Tetracomb Ointment is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid scratching affected areas.
- Wear loose, breathable clothing if possible.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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