Tetrazin
Generic Name
Tetrazin Hydrochloride 125 mg Tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tetrazin 125 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Tetrazin 125 mg tablet is an antidepressant used to treat major depressive disorder, generalized anxiety disorder, and certain other mood disorders. It works by balancing certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, may be increased to 125 mg daily after 1-2 weeks based on response and tolerability. Maximum 250 mg daily.
Elderly
Lower initial doses (e.g., 25 mg daily) and slower titration recommended due to potential for increased sensitivity and reduced renal clearance.
Renal_impairment
Dose adjustment required; for severe impairment, reduce dose by 50%.
How to Take
Oral, with or without food.
Mechanism of Action
Tetrazin is a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). It increases the levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells, thereby improving mood and reducing anxiety.
Pharmacokinetics
Onset
Initial effects may be seen within 1-2 weeks; full therapeutic effects typically observed after 4-6 weeks of consistent use.
Excretion
Excreted primarily through urine as metabolites.
Half life
Approximately 10-15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Tetrazin or any excipients
- Concomitant use with MAO inhibitors
- Uncontrolled narrow-angle glaucoma
Drug Interactions
SSRIs
Increased risk of serotonin syndrome.
Warfarin
Increased bleeding risk.
MAO Inhibitors
Risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include somnolence, dizziness, nausea, vomiting, tachycardia, and rarely, seizures or coma. Management is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if potential benefit outweighs risk. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Tetrazin or any excipients
- Concomitant use with MAO inhibitors
- Uncontrolled narrow-angle glaucoma
Drug Interactions
SSRIs
Increased risk of serotonin syndrome.
Warfarin
Increased bleeding risk.
MAO Inhibitors
Risk of serotonin syndrome.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include somnolence, dizziness, nausea, vomiting, tachycardia, and rarely, seizures or coma. Management is supportive and symptomatic.
Pregnancy & Lactation
Use during pregnancy only if potential benefit outweighs risk. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Multiple Phase 3 trials demonstrated efficacy in major depressive disorder and generalized anxiety disorder, showing statistically significant improvements in HAM-D and GAD-7 scores compared to placebo. Long-term safety and efficacy studies are ongoing.
Lab Monitoring
- Monitor liver function tests periodically
- Monitor serum sodium levels
Doctor Notes
- Gradual titration of Tetrazin is crucial to minimize initial adverse effects and improve patient tolerability.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents (e.g., SSRIs, triptans).
- Educate patients about the delayed onset of therapeutic effects and the importance of adherence.
Patient Guidelines
- Take as directed, do not stop abruptly without consulting your doctor.
- Report any worsening depression or suicidal thoughts immediately.
- Avoid alcohol consumption while taking this medicine.
Missed Dose Advice
Take as soon as remembered, unless it's almost time for the next dose. Do not double dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and exercise routine.
- Practice stress-reduction techniques like meditation or yoga.
- Ensure adequate sleep for better mood management.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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