Tezolin
Generic Name
Theophylline
Manufacturer
Square Pharmaceuticals Ltd. (Bangladesh)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tezolin 200 mg tablet | ৳ 500.00 | ৳ 1,000.00 |
Description
Overview of the medicine
Tezolin is a sustained-release tablet containing Theophylline, used to prevent and treat symptoms of asthma and other lung diseases such as COPD, by relaxing the airways and making breathing easier.
Uses & Indications
Dosage
Adults
Individualized based on serum theophylline levels, typically 200-400 mg twice daily for sustained-release formulations. Max 600 mg/day.
Elderly
Lower doses may be required due to decreased clearance.
Renal_impairment
No dosage adjustment needed for renal impairment, but caution with severe liver impairment.
How to Take
Take orally, usually twice daily, with or without food. Swallow whole, do not crush or chew sustained-release tablets.
Mechanism of Action
Theophylline works by relaxing the smooth muscles of the bronchi and blood vessels in the lungs. It inhibits phosphodiesterase, leading to an increase in intracellular cAMP, which results in bronchodilation. It also has anti-inflammatory effects and can improve diaphragmatic contractility.
Pharmacokinetics
Onset
Typically 1-2 hours for sustained-release formulations.
Excretion
Mainly excreted by the kidneys, with a small portion unchanged in urine.
Half life
Variable, ranging from 7-9 hours in adults, shorter in children and smokers, longer in elderly and those with liver impairment.
Absorption
Well absorbed from the gastrointestinal tract, though absorption rate can vary with sustained-release formulations.
Metabolism
Extensively metabolized in the liver, primarily by CYP1A2 and CYP2E1 enzymes.
Side Effects
Contraindications
- Hypersensitivity to theophylline or other xanthine derivatives
- Acute myocardial infarction
- Severe uncorrected arrhythmias
Drug Interactions
Phenytoin, Phenobarbital, Rifampin
May decrease theophylline levels, reducing efficacy.
Cimetidine, Erythromycin, Ciprofloxacin
May increase theophylline levels, leading to toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, restlessness, tremors, tachycardia, and seizures. Treatment involves discontinuation, activated charcoal, supportive care, and management of symptoms.
Pregnancy & Lactation
Use with caution during pregnancy, only if clearly needed. Theophylline is excreted into breast milk, monitor infants for signs of toxicity.
Side Effects
Contraindications
- Hypersensitivity to theophylline or other xanthine derivatives
- Acute myocardial infarction
- Severe uncorrected arrhythmias
Drug Interactions
Phenytoin, Phenobarbital, Rifampin
May decrease theophylline levels, reducing efficacy.
Cimetidine, Erythromycin, Ciprofloxacin
May increase theophylline levels, leading to toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, restlessness, tremors, tachycardia, and seizures. Treatment involves discontinuation, activated charcoal, supportive care, and management of symptoms.
Pregnancy & Lactation
Use with caution during pregnancy, only if clearly needed. Theophylline is excreted into breast milk, monitor infants for signs of toxicity.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Theophylline has been extensively studied in clinical trials for its efficacy in asthma and COPD management. Ongoing research explores its anti-inflammatory properties and optimal dosing strategies.
Lab Monitoring
- Monitor serum theophylline levels (therapeutic range: 10-20 mcg/mL), especially after initiation or dosage changes.
- Monitor liver and kidney function in patients with underlying impairment.
Doctor Notes
- Therapeutic drug monitoring is crucial to maintain efficacy and prevent toxicity.
- Counsel patients on the importance of adherence and signs of toxicity.
- Consider potential drug interactions, especially with CYP1A2 inhibitors/inducers.
Patient Guidelines
- Take doses regularly as prescribed.
- Do not crush, chew, or break sustained-release tablets.
- Report any new or worsening symptoms, especially cardiac or neurological.
- Avoid excessive caffeine intake.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or tremors in some individuals; caution is advised when driving or operating machinery.
Lifestyle Advice
- Avoid smoking as it can reduce theophylline levels.
- Maintain a healthy lifestyle to support respiratory health.
- Limit alcohol intake.
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