Thiotab
Generic Name
Thioctic Acid (Alpha-Lipoic Acid)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| thiotab 15 mg tablet | ৳ 0.72 | ৳ 7.20 |
Description
Overview of the medicine
Thiotab 15 mg tablet contains Thioctic Acid (Alpha-Lipoic Acid), a potent antioxidant naturally found in the body. It is involved in various metabolic processes and is often used as a dietary supplement for nerve health and blood sugar regulation.
Uses & Indications
Dosage
Adults
Typically, 1-2 tablets (15-30 mg) once daily, or as directed by a healthcare professional. For therapeutic uses like diabetic neuropathy, much higher doses (e.g., 300-600 mg daily) are usually prescribed.
Elderly
No specific dosage adjustment for elderly; use with caution.
Renal_impairment
No specific dosage adjustment required; use with caution in severe renal impairment.
How to Take
Oral administration. Can be taken with or without food. For better absorption, sometimes advised on an empty stomach.
Mechanism of Action
Thioctic acid is a coenzyme in mitochondrial dehydrogenase complexes, participating in energy metabolism. It is a powerful antioxidant that scavenges free radicals, regenerates other antioxidants (like vitamins C and E, and glutathione), and chelates metal ions. It can improve nerve function, glucose utilization, and reduce oxidative stress.
Pharmacokinetics
Onset
Therapeutic effects may take weeks or months of consistent use for conditions like neuropathy.
Excretion
Mainly excreted renally as metabolites.
Half life
Short elimination half-life, approximately 20-50 minutes, but its metabolites and effects persist longer.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 30-60 minutes. Bioavailability is variable, typically 30-60% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily via beta-oxidation and S-methylation.
Side Effects
Contraindications
- Hypersensitivity to thioctic acid or any component of the formulation.
- Children and adolescents (due to insufficient clinical experience with higher doses; for 15mg it's generally safe but still caution).
Drug Interactions
Cisplatin
May reduce the efficacy of cisplatin.
Insulin and oral antidiabetic agents
May potentiate the hypoglycemic effect; blood glucose monitoring advised.
Metal compounds (e.g., iron, magnesium, calcium supplements)
Thioctic acid is a chelator, so separate administration by several hours is recommended.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is rare but may lead to nausea, vomiting, headache, and in very high doses, hypoglycemia, and lactic acidosis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Limited data available. Use during pregnancy and lactation is generally not recommended unless clearly necessary and the potential benefits outweigh the risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to thioctic acid or any component of the formulation.
- Children and adolescents (due to insufficient clinical experience with higher doses; for 15mg it's generally safe but still caution).
Drug Interactions
Cisplatin
May reduce the efficacy of cisplatin.
Insulin and oral antidiabetic agents
May potentiate the hypoglycemic effect; blood glucose monitoring advised.
Metal compounds (e.g., iron, magnesium, calcium supplements)
Thioctic acid is a chelator, so separate administration by several hours is recommended.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is rare but may lead to nausea, vomiting, headache, and in very high doses, hypoglycemia, and lactic acidosis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Limited data available. Use during pregnancy and lactation is generally not recommended unless clearly necessary and the potential benefits outweigh the risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies
Approval Status
Approved by regulatory authorities (e.g., DGDA) as a supplement/adjuvant therapy
Patent Status
Generic
Clinical Trials
Numerous clinical trials have investigated the efficacy of thioctic acid in diabetic neuropathy and as an antioxidant. Results generally support its role as an adjuvant therapy, particularly at higher doses.
Lab Monitoring
- Blood glucose levels (especially in diabetic patients taking antidiabetic medication)
- Liver function tests (in patients with pre-existing liver conditions or on long-term therapy)
Doctor Notes
- Advise patients on potential hypoglycemic effects if diabetic.
- Recommend separating administration from metal-containing supplements.
- Emphasize its role as an adjuvant/supplement, not a primary treatment for severe conditions.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, it does not affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet.
- Regular exercise may help manage underlying conditions.
- Avoid smoking and excessive alcohol consumption.
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