Tigel
Generic Name
Ticagrelor
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tigel 60 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Ticagrelor is an oral, reversibly binding, direct-acting P2Y12 receptor antagonist that prevents platelet aggregation and reduces the risk of thrombotic cardiovascular events. The 60 mg dose is often used for long-term prevention after a heart attack.
Uses & Indications
Dosage
Adults
60 mg twice daily, in combination with aspirin (usually low-dose 75-100 mg daily).
Elderly
No dose adjustment needed.
Renal_impairment
No dose adjustment needed.
How to Take
Oral, with or without food.
Mechanism of Action
Selectively and reversibly binds to the P2Y12 receptor on platelets, preventing ADP-mediated platelet activation and aggregation.
Pharmacokinetics
Onset
~30 minutes.
Excretion
Primarily via bile/feces (58%), minor renal (26%).
Half life
Ticagrelor: ~6-13 hours; Active metabolite: ~7-15 hours.
Absorption
Rapidly absorbed. Tmax approx 1.5 hours. Bioavailability 36%.
Metabolism
Primarily hepatic via CYP3A4 to an active metabolite.
Side Effects
Contraindications
- Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
- History of intracranial hemorrhage.
- Severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir).
- Hypersensitivity to ticagrelor or any component of the tablet.
Drug Interactions
Digoxin
Increased digoxin exposure.
Simvastatin/Lovastatin
Increased statin exposure.
Strong CYP3A4 inducers (e.g., rifampin, phenytoin)
Decreased ticagrelor exposure.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
Increased ticagrelor exposure.
Other antiplatelet agents, anticoagulants (e.g., warfarin, heparin)
Increased bleeding risk.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to increased bleeding risk. Management includes supportive care; platelet transfusion has limited efficacy.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding.
Side Effects
Contraindications
- Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
- History of intracranial hemorrhage.
- Severe hepatic impairment.
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir).
- Hypersensitivity to ticagrelor or any component of the tablet.
Drug Interactions
Digoxin
Increased digoxin exposure.
Simvastatin/Lovastatin
Increased statin exposure.
Strong CYP3A4 inducers (e.g., rifampin, phenytoin)
Decreased ticagrelor exposure.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
Increased ticagrelor exposure.
Other antiplatelet agents, anticoagulants (e.g., warfarin, heparin)
Increased bleeding risk.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to increased bleeding risk. Management includes supportive care; platelet transfusion has limited efficacy.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Patented (active ingredient)
WHO Essential Medicine
YesClinical Trials
Key clinical trials include PLATO (for 90 mg dose) and PEGASUS-TIMI 54 (for 60 mg dose), demonstrating efficacy in reducing cardiovascular events.
Lab Monitoring
- Hemoglobin and hematocrit levels
- Platelet count
- Renal function tests
- Liver function tests (if indicated)
Doctor Notes
- Emphasize the importance of patient adherence to concomitant low-dose aspirin therapy.
- Careful assessment of bleeding risk vs. ischemic benefit is necessary, especially in elderly patients or those with risk factors for bleeding.
- Advise patients to inform all healthcare professionals about ticagrelor use.
Patient Guidelines
- Take Tigel exactly as prescribed by your doctor.
- Do not stop taking this medicine without consulting your doctor, even if you feel well.
- Report any unusual or prolonged bleeding immediately to your doctor.
- Inform all healthcare providers, including dentists, that you are taking Tigel before any surgery or dental procedures.
Missed Dose Advice
If a dose is missed, take the next dose at its regularly scheduled time. Do not take a double dose.
Driving Precautions
Tigel may cause dizziness. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid activities that increase the risk of bleeding or injury.
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, as advised by your doctor.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Tigel Brand
Other medicines available under the same brand name
