Tigel
Generic Name
Tigecycline
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tigel 90 mg tablet | ৳ 75.00 | ৳ 750.00 |
Description
Overview of the medicine
Tigel 90 mg tablet contains tigecycline, a glycylcycline antibiotic used to treat complicated skin and skin structure infections (cSSSI) and complicated intra-abdominal infections (cIAI) caused by susceptible bacteria. Note: Tigecycline is typically an intravenous drug; this oral tablet formulation is hypothetical.
Uses & Indications
Dosage
Adults
Initial loading dose of 90 mg, followed by 90 mg every 12 hours for 5 to 14 days, depending on the type and severity of infection. (Hypothetical for oral form, based on IV regimen).
Elderly
No dose adjustment is required based on age alone.
Renal_impairment
No dose adjustment is required for mild to severe renal impairment or in patients undergoing hemodialysis.
How to Take
Take Tigel 90 mg tablet orally with a glass of water, with or without food. Swallow the tablet whole; do not crush, chew, or split it.
Mechanism of Action
Tigecycline inhibits protein synthesis by binding to the 30S ribosomal subunit, preventing the entry of aminoacyl-tRNA molecules into the A site. This action makes it bacteriostatic.
Pharmacokinetics
Onset
1-2 hours (hypothetical for oral form).
Excretion
Primarily excreted unchanged in bile/feces (59%), with minor renal excretion (22%).
Half life
Approximately 27-48 hours.
Absorption
Rapidly absorbed from the GI tract (hypothetical for oral form). Peak plasma concentration (Tmax) in 2-3 hours. Bioavailability is estimated to be around 30-40% for this hypothetical oral formulation.
Metabolism
Limited metabolism; primarily undergoes glucuronidation, N-acetylation, and epimerization.
Side Effects
Contraindications
- Known hypersensitivity to tigecycline or any tetracycline antibiotic.
- Children under 8 years of age due to potential for permanent tooth discoloration and inhibition of bone growth.
Drug Interactions
Warfarin
May prolong prothrombin time (PT) and International Normalized Ratio (INR), requiring close monitoring.
Oral contraceptives
Tigecycline may reduce the effectiveness of oral contraceptives. Advise patients to use an alternative or additional method of contraception.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for tigecycline overdose. Management should involve symptomatic and supportive treatment. Hemodialysis is not effective in removing tigecycline from the body.
Pregnancy & Lactation
Pregnancy Category D. Avoid during pregnancy due to potential for fetal harm (e.g., bone growth inhibition, permanent tooth discoloration). Avoid during lactation as it is excreted in breast milk and may affect the infant.
Side Effects
Contraindications
- Known hypersensitivity to tigecycline or any tetracycline antibiotic.
- Children under 8 years of age due to potential for permanent tooth discoloration and inhibition of bone growth.
Drug Interactions
Warfarin
May prolong prothrombin time (PT) and International Normalized Ratio (INR), requiring close monitoring.
Oral contraceptives
Tigecycline may reduce the effectiveness of oral contraceptives. Advise patients to use an alternative or additional method of contraception.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for tigecycline overdose. Management should involve symptomatic and supportive treatment. Hemodialysis is not effective in removing tigecycline from the body.
Pregnancy & Lactation
Pregnancy Category D. Avoid during pregnancy due to potential for fetal harm (e.g., bone growth inhibition, permanent tooth discoloration). Avoid during lactation as it is excreted in breast milk and may affect the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in hospitals and pharmacies (assuming oral formulation)
Approval Status
FDA approved (for IV form)
Patent Status
Expired (generic versions available)
Clinical Trials
Extensive clinical trial data are available for the intravenous formulation of tigecycline regarding its efficacy and safety in cSSSI and cIAI. Specific trials for an oral 90 mg tablet formulation would be required for its approval.
Lab Monitoring
- Liver function tests (LFTs) should be monitored regularly.
- Renal function tests.
- Complete blood count (CBC).
- INR/PT for patients on warfarin.
Doctor Notes
- Emphasize the Black Box Warning regarding increased all-cause mortality, and discuss this risk with patients.
- Tigel (tigecycline) is not indicated for the treatment of diabetic foot infections or bloodstream infections.
- Monitor for signs of superinfection and Clostridium difficile-associated diarrhea.
Patient Guidelines
- Complete the full prescribed course of Tigel, even if symptoms improve, to prevent the development of antibiotic resistance.
- Report any severe or persistent diarrhea, abdominal pain, or allergic reactions immediately.
- Avoid excessive exposure to direct sunlight or artificial UV light and use protective measures (e.g., sunscreen) due to photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tigel may cause dizziness or visual disturbances. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain adequate hydration throughout the treatment period.
- Avoid alcohol consumption while on Tigel.
- Ensure a balanced diet to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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