Tigover
Generic Name
Teneligliptin
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tigover 10 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Teneligliptin is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus. It belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitor class, which works by increasing incretin levels in the body.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily (i.e., two 10 mg tablets). Dosage may be adjusted based on individual patient response and tolerance.
Elderly
No dose adjustment generally required, but caution is advised.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe renal impairment or end-stage renal disease (ESRD), caution is advised.
How to Take
Orally, once daily, with or without food.
Mechanism of Action
Teneligliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which is responsible for inactivating incretin hormones (GLP-1 and GIP). By inhibiting DPP-4, Teneligliptin increases the circulating levels of active incretin hormones, which, in turn, enhance glucose-dependent insulin secretion from pancreatic beta cells and suppress glucagon secretion from pancreatic alpha cells. This leads to improved glycemic control.
Pharmacokinetics
Onset
Within hours of administration, significant DPP-4 inhibition observed.
Excretion
Excreted both renally (about 30-50%) and hepatically (about 60-70%), predominantly as metabolites.
Half life
Approximately 15 hours.
Absorption
Rapidly absorbed. Peak plasma concentration (Tmax) is reached in about 1-2 hours. Bioavailability is high (approx. 60-70%).
Metabolism
Primarily metabolized by CYP3A4 and flavin-containing monooxygenase (FMO1 and FMO3) in the liver.
Side Effects
Contraindications
- Hypersensitivity to Teneligliptin or any component of the formulation
- Type 1 Diabetes Mellitus
- Diabetic Ketoacidosis
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Possible altered anticoagulant effect.
CYP3A4/FMO inhibitors/inducers
May affect Teneligliptin metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypoglycemia (especially if combined with insulin or sulfonylurea) and gastrointestinal discomfort. Management involves symptomatic and supportive treatment, including monitoring of blood glucose levels.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is not known if Teneligliptin is excreted in human milk; exercise caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Teneligliptin or any component of the formulation
- Type 1 Diabetes Mellitus
- Diabetic Ketoacidosis
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Possible altered anticoagulant effect.
CYP3A4/FMO inhibitors/inducers
May affect Teneligliptin metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypoglycemia (especially if combined with insulin or sulfonylurea) and gastrointestinal discomfort. Management involves symptomatic and supportive treatment, including monitoring of blood glucose levels.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is not known if Teneligliptin is excreted in human milk; exercise caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to product packaging for exact date.
Availability
Pharmacies, Hospitals
Approval Status
Approved in many countries including Bangladesh (DGDA)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Teneligliptin in improving glycemic control in patients with type 2 diabetes mellitus.
Lab Monitoring
- HbA1c levels regularly
- Blood glucose levels (fasting and postprandial)
- Renal function (creatinine, GFR) periodically
Doctor Notes
- Counsel patients on the importance of diet, exercise, and regular blood glucose monitoring.
- Educate patients on the symptoms and management of hypoglycemia, especially if concomitant insulin or sulfonylurea is prescribed.
- Periodically assess renal function, although dose adjustment is not typically required for mild to moderate impairment.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Be aware of hypoglycemia symptoms and how to manage them.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some patients, especially if hypoglycemia occurs. Advise caution or avoid driving if affected.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular physical activity.
- Monitor blood glucose levels regularly.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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