Timonate
Generic Name
Timonate
Manufacturer
Aarogya Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| timonate 50 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Timonate 50 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, inflammation, and fever. It acts by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme.
Uses & Indications
Dosage
Adults
50 mg once daily, or 25 mg twice daily, adjusted based on patient response and tolerability. Max 100 mg/day.
Elderly
Initiate with the lowest effective dose, monitor for adverse effects. Consider 25 mg once daily.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment. Not recommended for eGFR < 30 mL/min.
How to Take
Timonate 50 mg Tablet should be taken orally with a glass of water, with or without food. Taking it with food may reduce gastrointestinal discomfort.
Mechanism of Action
Timonate selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins involved in pain, inflammation, and fever. By blocking COX-2, it reduces the production of these inflammatory mediators, thereby alleviating symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesic effect.
Excretion
Mainly excreted in urine (approximately 50-60%) and feces (approximately 25-30%) as metabolites.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached within 2-3 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to Timonate or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma concentrations and toxicity.
Warfarin
Increased risk of bleeding due to enhanced anticoagulant effect.
Diuretics and ACE inhibitors
May reduce the antihypertensive effect and increase risk of renal impairment.
Other NSAIDs/Corticosteroids
Increased risk of gastrointestinal adverse effects.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential fetal cardiovascular effects. During the first two trimesters and lactation, use only if clearly needed and the potential benefit outweighs the risk, under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to Timonate or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase lithium plasma concentrations and toxicity.
Warfarin
Increased risk of bleeding due to enhanced anticoagulant effect.
Diuretics and ACE inhibitors
May reduce the antihypertensive effect and increase risk of renal impairment.
Other NSAIDs/Corticosteroids
Increased risk of gastrointestinal adverse effects.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential fetal cardiovascular effects. During the first two trimesters and lactation, use only if clearly needed and the potential benefit outweighs the risk, under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in all registered pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Patent Pending
Clinical Trials
Clinical trials demonstrated significant efficacy in reducing pain and inflammation associated with osteoarthritis and rheumatoid arthritis, with a favorable gastrointestinal safety profile compared to non-selective NSAIDs.
Lab Monitoring
- Complete blood count (CBC) for long-term therapy
- Liver function tests (LFTs) periodically
- Kidney function tests (Serum creatinine, eGFR) regularly, especially in elderly or patients with renal impairment
- Blood pressure monitoring
Doctor Notes
- Advise patients on the importance of taking the lowest effective dose for the shortest duration necessary.
- Counsel patients on potential cardiovascular and gastrointestinal risks, especially those with pre-existing conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual symptoms like black stools or severe abdominal pain immediately.
- Avoid self-medication for prolonged periods.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. Patients should be cautious when driving or operating machinery until they know how Timonate affects them.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Limit alcohol intake while on this medication.
- Engage in regular, moderate exercise if appropriate for your condition.
- Manage stress effectively to improve overall well-being.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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