Tinabil
Generic Name
Tinabil
Manufacturer
Meditopix Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tinabil 20 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Tinabil 20 mg Tablet is a lipid-lowering medication used to reduce cholesterol and triglyceride levels in the blood. It belongs to a class of drugs called statins, which work by inhibiting an enzyme in the liver responsible for cholesterol production. It is used in conjunction with diet and exercise to prevent cardiovascular diseases.
Uses & Indications
Dosage
Adults
The usual starting dose is 10-20 mg once daily. For primary hypercholesterolemia or mixed dyslipidemia, the typical dose is 20 mg once daily. The maximum dose is 40 mg once daily.
Elderly
No dosage adjustment required for elderly patients with normal renal function. A starting dose of 5 mg once daily may be considered for patients over 70 years.
Renal_impairment
For patients with moderate renal impairment (creatinine clearance <60 mL/min), a starting dose of 5 mg once daily is recommended. The 40 mg dose is contraindicated in severe renal impairment.
How to Take
Tinabil tablets should be swallowed whole with water, once daily, with or without food. It is generally recommended to take the dose at the same time each day, preferably in the evening.
Mechanism of Action
Tinabil selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the early, rate-limiting step in cholesterol biosynthesis. This inhibition reduces the production of mevalonate, a precursor to cholesterol. This results in a decrease in hepatic cholesterol synthesis and an increase in the number of hepatic LDL receptors on the cell surface, enhancing uptake and catabolism of LDL. It also reduces VLDL and triglyceride levels.
Pharmacokinetics
Onset
Cholesterol-lowering effect typically starts within 1-2 weeks; maximal effect within 2-4 weeks.
Excretion
Mainly excreted in the feces via biliary route; a small portion is excreted in urine.
Half life
Approximately 19 hours.
Absorption
Rapidly absorbed from the GI tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver, mainly by CYP2C9 and CYP3A4, to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Tinabil or any component of the tablet.
- Active liver disease, including unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Severe renal impairment (creatinine clearance <30 mL/min).
- Concomitant use of cyclosporine.
Drug Interactions
Warfarin
Potentiation of anticoagulant effect.
Cyclosporine
Increased Tinabil exposure, contraindicated.
Erythromycin
Increased Tinabil exposure.
Gemfibrozil and other fibrates
Increased risk of myopathy/rhabdomyolysis.
Protease inhibitors (e.g., Atazanavir/Ritonavir)
Increased Tinabil exposure.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for Tinabil overdose. In the event of an overdose, treatment should be symptomatic and supportive. Monitor liver function and CK levels. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Tinabil is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment.
Side Effects
Contraindications
- Hypersensitivity to Tinabil or any component of the tablet.
- Active liver disease, including unexplained persistent elevations of serum transaminases.
- Pregnancy and lactation.
- Severe renal impairment (creatinine clearance <30 mL/min).
- Concomitant use of cyclosporine.
Drug Interactions
Warfarin
Potentiation of anticoagulant effect.
Cyclosporine
Increased Tinabil exposure, contraindicated.
Erythromycin
Increased Tinabil exposure.
Gemfibrozil and other fibrates
Increased risk of myopathy/rhabdomyolysis.
Protease inhibitors (e.g., Atazanavir/Ritonavir)
Increased Tinabil exposure.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific treatment for Tinabil overdose. In the event of an overdose, treatment should be symptomatic and supportive. Monitor liver function and CK levels. Hemodialysis is unlikely to be of benefit.
Pregnancy & Lactation
Tinabil is contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Tinabil has undergone extensive clinical trials demonstrating its efficacy and safety in reducing lipid levels and cardiovascular risk, similar to other approved statins.
Lab Monitoring
- Liver function tests (LFTs) should be performed before initiating treatment and at 12 weeks following initiation of therapy or dose elevation, and periodically thereafter (e.g., every 6-12 months).
- Creatine kinase (CK) levels should be measured before treatment in patients with risk factors for myopathy and if muscle symptoms occur during treatment.
Doctor Notes
- Emphasize the importance of lifestyle modifications alongside pharmacotherapy.
- Regularly monitor liver function tests and CK levels, especially if myalgia occurs.
- Counsel patients on potential drug interactions and contraindicated medications.
Patient Guidelines
- Take Tinabil as prescribed by your doctor, usually once daily.
- Continue with a cholesterol-lowering diet and exercise program.
- Report any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tinabil has no or negligible influence on the ability to drive and use machines. However, some individuals may experience dizziness, so caution is advised until you know how you react to the medication.
Lifestyle Advice
- Adopt a healthy diet low in saturated and trans fats.
- Engage in regular physical activity.
- Maintain a healthy weight and quit smoking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Tinabil Brand
Other medicines available under the same brand name
