Adults

Dosage for Tinidazole typically ranges from 500 mg to 2 g, depending on the indication. For 50 mg formulation, specific dosage should be strictly followed as prescribed by a physician, as this strength is unusual for standard indications.

Elderly

No specific dosage adjustment is generally required, but caution is advised in patients with impaired renal or hepatic function.

Renal_impairment

In severe renal impairment (creatinine clearance <10 mL/min), the dosage interval may need to be prolonged, or the dose reduced. Consultation with a physician is recommended.

Onset

Within 1-2 hours for systemic effects.

Excretion

Excreted by both renal (approximately 20-25% as unchanged drug) and fecal routes.

Half life

Approximately 12-14 hours, allowing for once-daily or single-dose regimens.

Absorption

Rapidly and completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 2 hours.

Metabolism

Primarily metabolized in the liver by oxidation, hydroxylation, and conjugation.

Alcohol

Disulfiram-like reaction (abdominal cramps, nausea, vomiting, headache, flushing) when consumed during or within 72 hours of treatment.

Cimetidine

May reduce the hepatic metabolism of tinidazole, potentially increasing its plasma concentrations.

Warfarin and other oral anticoagulants

May potentiate the anticoagulant effect, requiring close monitoring of INR and dose adjustment.