Tivanik
Generic Name
Azithromycin
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tivanik 250 mg tablet | ৳ 8.03 | ৳ 48.18 |
Description
Overview of the medicine
Tivanik 250 mg Tablet contains Azithromycin, a macrolide antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For most infections, 500 mg once daily for 3 days OR 500 mg as a single dose on day 1, followed by 250 mg once daily for 4 days. For STIs, a single 1g dose (four 250mg tablets) is common.
Elderly
No specific dosage adjustment is recommended for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment (creatinine clearance >40 mL/min). Data is limited for severe impairment.
How to Take
Tivanik tablets can be taken with or without food. However, taking it with food may help reduce gastrointestinal upset. Swallow the tablet whole with water.
Mechanism of Action
Azithromycin binds to the 50S ribosomal subunit of susceptible microorganisms and, thus, inhibits protein synthesis. This results in the inhibition of the bacterium's growth and reproduction.
Pharmacokinetics
Onset
Peak plasma concentrations are generally achieved within 2 to 3 hours.
Excretion
Mainly excreted unchanged in the bile; a small proportion (around 6%) is excreted renally.
Half life
Prolonged terminal elimination half-life of 2 to 4 days, allowing for once-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; however, bioavailability is approximately 37% due to significant first-pass metabolism.
Metabolism
Primarily metabolized in the liver, likely via demethylation, without significant CYP450 involvement.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Antacids
Concurrent use of antacids containing aluminum or magnesium may reduce the peak serum concentration of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations. Adjust azithromycin dose.
QT-prolonging drugs
Increased risk of cardiac arrhythmias. Use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment involves symptomatic and supportive measures as clinically indicated.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Antacids
Concurrent use of antacids containing aluminum or magnesium may reduce the peak serum concentration of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased azithromycin concentrations. Adjust azithromycin dose.
QT-prolonging drugs
Increased risk of cardiac arrhythmias. Use with caution.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Treatment involves symptomatic and supportive measures as clinically indicated.
Pregnancy & Lactation
Pregnancy Category B. Azithromycin should be used during pregnancy only if clearly needed. It is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Ongoing research explores its potential in new indications and formulations.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment)
- Renal function tests (in severe renal impairment)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Consider susceptibility testing if no clinical improvement is observed.
- Advise patients about the importance of completing the full course to prevent resistance.
- Be aware of potential for QT prolongation, especially in patients with pre-existing cardiac conditions or on other QT-prolonging drugs.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve.
- Do not share your medicine with others.
- Report any severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Tivanik may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Get adequate rest to aid recovery.
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