Tivanik
Generic Name
Tivanofloxacin 500 mg tablet
Manufacturer
Medicure Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tivanik 500 mg tablet | ৳ 15.06 | ৳ 60.24 |
Description
Overview of the medicine
Tivanik 500 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections including respiratory tract infections, urinary tract infections, skin and soft tissue infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 7-14 days depending on infection severity.
Elderly
No specific dose adjustment required based on age; adjust based on renal function.
Renal_impairment
Creatinine clearance 30-50 mL/min: 250 mg once daily. CrCl <30 mL/min: 250 mg every 48 hours.
How to Take
Administer orally with or without food. Do not crush or chew the tablet.
Mechanism of Action
Tivanofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
1-2 hours for significant plasma concentrations
Excretion
Primarily excreted unchanged in urine and feces
Half life
Approximately 6-8 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Bioavailability approximately 90%.
Metabolism
Minimally metabolized in the liver (CYP450 independent pathway)
Side Effects
Contraindications
- Hypersensitivity to Tivanofloxacin or other fluoroquinolones
- History of tendon rupture associated with quinolone use
Drug Interactions
Warfarin
Potentiation of anticoagulant effect.
Corticosteroids
Increased risk of tendinopathy.
Iron or Zinc supplements
Reduced absorption of Tivanofloxacin.
Antacids containing aluminum or magnesium
Reduced absorption of Tivanofloxacin.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Symptomatic and supportive treatment is recommended. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to excretion into breast milk and potential for arthropathy in infants.
Side Effects
Contraindications
- Hypersensitivity to Tivanofloxacin or other fluoroquinolones
- History of tendon rupture associated with quinolone use
Drug Interactions
Warfarin
Potentiation of anticoagulant effect.
Corticosteroids
Increased risk of tendinopathy.
Iron or Zinc supplements
Reduced absorption of Tivanofloxacin.
Antacids containing aluminum or magnesium
Reduced absorption of Tivanofloxacin.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Symptomatic and supportive treatment is recommended. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to excretion into breast milk and potential for arthropathy in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patented
Clinical Trials
Extensive clinical trials demonstrated efficacy and safety in various bacterial infections.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with impaired renal function
- Liver function tests in patients with hepatic impairment or during prolonged treatment
Doctor Notes
- Assess patient for risk factors for tendinopathy (e.g., age >60, corticosteroid use, renal failure) before prescribing.
- Advise patients about potential serious adverse effects and to discontinue and seek medical attention if they occur.
- Consider alternative antibiotics for uncomplicated infections where fluoroquinolones are not first-line.
Patient Guidelines
- Complete the full course of antibiotics even if symptoms improve.
- Stay well-hydrated.
- Avoid excessive sun exposure.
- Report any pain or swelling in tendons immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. Patients should exercise caution when driving or operating machinery until they know how Tivanik affects them.
Lifestyle Advice
- Maintain a balanced diet.
- Avoid alcohol during treatment.
- Get adequate rest.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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