Tobidex
Generic Name
Tobramycin + Dexamethasone Ophthalmic Ointment
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tobidex 01 03 eye ointment | ৳ 90.27 | N/A |
Description
Overview of the medicine
Tobidex Eye Ointment is a combination of an antibiotic (Tobramycin) and a corticosteroid (Dexamethasone) used to treat ocular inflammatory conditions where bacterial infection or risk of bacterial infection exists.
Uses & Indications
Dosage
Adults
Apply a small amount (approximately a 1/2 inch ribbon) into the conjunctival sac three to four times daily.
Elderly
Same as adult dosage. No specific dosage adjustment is generally required.
Renal_impairment
No specific dosage adjustment required due to minimal systemic absorption from ophthalmic use.
How to Take
For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch. Apply a small ribbon of ointment into the pouch. Close eye gently for 1-2 minutes. Do not touch the tip of the tube to the eye or any other surface.
Mechanism of Action
Tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to bactericidal effects. Dexamethasone is a potent corticosteroid that suppresses the inflammatory response by inhibiting multiple inflammatory mediators, thereby reducing swelling, redness, and itching.
Pharmacokinetics
Onset
Anti-inflammatory effects of Dexamethasone can be observed within hours; complete antibiotic effect on infection may take several days.
Excretion
Absorbed Tobramycin is primarily excreted renally; Dexamethasone metabolites are excreted via hepatic pathways.
Half life
Systemic half-life not clinically relevant due to minimal ophthalmic absorption.
Absorption
Minimal systemic absorption occurs following ophthalmic administration, thus systemic effects are generally negligible.
Metabolism
Dexamethasone is metabolized in the liver; Tobramycin is primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to any component of the medication.
- Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva.
- Mycobacterial infection of the eye.
- Fungal diseases of ocular structures.
- Untreated purulent infection of the eye.
Drug Interactions
Systemic Drugs
No significant systemic drug interactions are expected due to minimal ocular absorption.
Other Ophthalmic Preparations
If using other eye drops or ointments, administer them at least 5-10 minutes apart.
Storage
Store at room temperature (15-30°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with ophthalmic administration. If irritation or excessive watering occurs, flush the eye with lukewarm water.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to any component of the medication.
- Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva.
- Mycobacterial infection of the eye.
- Fungal diseases of ocular structures.
- Untreated purulent infection of the eye.
Drug Interactions
Systemic Drugs
No significant systemic drug interactions are expected due to minimal ocular absorption.
Other Ophthalmic Preparations
If using other eye drops or ointments, administer them at least 5-10 minutes apart.
Storage
Store at room temperature (15-30°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with ophthalmic administration. If irritation or excessive watering occurs, flush the eye with lukewarm water.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to the expiry date on the packaging (typically 24-36 months). Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
Clinical Trials
The efficacy and safety of Tobramycin and Dexamethasone ophthalmic preparations are well-established through numerous clinical trials for their individual components and combination formulations.
Lab Monitoring
- Regular monitoring of intraocular pressure (IOP) is advised, especially with prolonged use (more than 10 days).
- Periodic slit-lamp examination is recommended for prolonged therapy.
Doctor Notes
- Emphasize the importance of short-term use and strictly follow the prescribed duration to minimize corticosteroid-related side effects.
- Monitor intraocular pressure regularly if therapy extends beyond 10 days.
- Advise patients about the potential for temporary blurred vision and caution regarding driving or operating machinery.
Patient Guidelines
- Wash hands thoroughly before and after applying the ointment.
- Do not touch the tip of the tube to the eye or any other surface to avoid contamination.
- Remove contact lenses before application and wait at least 15 minutes before reinserting, if allowed by your doctor.
- Do not wear contact lenses if you have an eye infection.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This ointment may cause temporary blurred vision or other visual disturbances. If vision is blurred, do not drive or operate machinery until your vision is clear.
Lifestyle Advice
- Avoid rubbing your eyes.
- Maintain good eye hygiene during treatment.
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