Toco
Generic Name
Tocophersolan (Vitamin E)
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| toco 675 mg injection | ৳ 1,750.00 | N/A |
Description
Overview of the medicine
Toco 675 mg Injection contains Tocophersolan, a water-soluble derivative of Vitamin E, used to treat or prevent Vitamin E deficiency, particularly in patients with malabsorption disorders such as cystic fibrosis, chronic cholestasis, or short bowel syndrome. It is essential for normal neurological function and acts as an antioxidant.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the severity of deficiency and underlying condition. Typically, 15-25 mg/kg/day intravenously, or as directed by a physician. The 675 mg vial might be used for daily or spaced dosing based on clinical need.
Elderly
Similar to adult dosage, but with caution, considering potential comorbidities and polypharmacy. Regular monitoring of Vitamin E levels is recommended.
Renal_impairment
No specific dose adjustments are typically required for mild to moderate renal impairment. For severe impairment, caution is advised, and monitoring of Vitamin E levels might be prudent due to altered excretion.
How to Take
Administer by slow intravenous (IV) infusion, usually diluted in an appropriate intravenous fluid (e.g., normal saline or dextrose solution). The infusion rate should be carefully controlled.
Mechanism of Action
Tocophersolan delivers Vitamin E (alpha-tocopherol) which acts as a potent lipid-soluble antioxidant, protecting cell membranes from oxidative damage by scavenging free radicals. It also plays a role in immune function, cell signaling, and gene expression.
Pharmacokinetics
Onset
Rapid due to intravenous administration.
Excretion
Excreted primarily via bile into feces, with a smaller amount excreted in urine.
Half life
Variable, typically ranges from hours to days, depending on distribution and storage in tissues.
Absorption
Administered intravenously, absorption is bypassed, and the drug is directly available systemically.
Metabolism
Primarily metabolized in the liver to various glucuronide and sulfate conjugates.
Side Effects
Contraindications
- •Hypersensitivity to Tocophersolan or any component of the formulation.
- •Severe bleeding disorders or active hemorrhage, especially with very high doses.
Drug Interactions
Orlistat
May reduce the absorption of fat-soluble vitamins, including Vitamin E, if taken orally.
Iron supplements
Vitamin E can interfere with the absorption and utilization of iron. Administer separately if possible.
Anticoagulants (e.g., Warfarin)
High doses of Vitamin E may enhance the anticoagulant effect of Warfarin, increasing the risk of bleeding. Close monitoring of INR/PT is recommended.
Storage
Store below 25°C (77°F). Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include fatigue, headache, nausea, diarrhea, abdominal cramps, and blurred vision. High doses may increase bleeding risk. Treatment is supportive; discontinue the drug and manage symptoms as appropriate.
Pregnancy & Lactation
Vitamin E is generally considered safe during pregnancy and lactation at recommended dietary allowance (RDA) doses. However, high doses should be used with caution and only if clearly needed, under medical supervision. Consult your doctor before use if pregnant or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, refer to the product label for exact dates.
Availability
Hospital pharmacies, Retail pharmacies
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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