Topicort
Generic Name
Desoximetasone
Manufacturer
Sanofi (original), various generics
Country
USA (original), various countries for generics
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| topicort 1 cream | ৳ 70.00 | N/A |
Description
Overview of the medicine
Topicort (Desoximetasone) is a topical corticosteroid used to reduce inflammation, itching, and redness caused by various skin conditions such as psoriasis and eczema.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin areas once or twice daily.
Elderly
Same as adult dosage; use with caution due to potential for thinner skin.
Renal_impairment
No specific dose adjustment required; minimal systemic absorption.
How to Take
For topical use only. Apply a thin film to the affected skin area and rub in gently. Wash hands before and after application. Avoid contact with eyes, nose, mouth, and mucous membranes.
Mechanism of Action
Desoximetasone works by activating naturally occurring corticosteroids in the skin, which in turn inhibits the release of inflammatory mediators (e.g., prostaglandins, leukotrienes) and causes vasoconstriction, thereby reducing inflammation, itching, and redness.
Pharmacokinetics
Onset
Clinical effects typically observed within days.
Excretion
Excreted primarily by the kidneys.
Half life
Not well-defined for topical application due to minimal systemic absorption; systemic half-life of absorbed drug is approximately 9.2 hours.
Absorption
Minimal systemic absorption through intact skin; absorption increases with skin damage, occlusion, and application to large areas.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to desoximetasone or any component of the formulation
- Untreated fungal, bacterial, or viral skin infections
- Rosacea
- Perioral dermatitis
- Acne vulgaris
Drug Interactions
Drugs that affect CYP3A4 metabolism
Although minimal for topical, theoretical potential for altered metabolism of desoximetasone.
Minimal systemic absorption, so drug interactions are rare. However, caution with other systemic corticosteroids.
Potential for additive systemic corticosteroid effects if significant absorption occurs.
Storage
Store at controlled room temperature (20-25°C or 68-77°F). Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely. Chronic overdose may lead to symptoms of Cushing's syndrome, hyperglycemia, and other manifestations of hypercorticism. Treatment is symptomatic and supportive; gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to desoximetasone or any component of the formulation
- Untreated fungal, bacterial, or viral skin infections
- Rosacea
- Perioral dermatitis
- Acne vulgaris
Drug Interactions
Drugs that affect CYP3A4 metabolism
Although minimal for topical, theoretical potential for altered metabolism of desoximetasone.
Minimal systemic absorption, so drug interactions are rare. However, caution with other systemic corticosteroids.
Potential for additive systemic corticosteroid effects if significant absorption occurs.
Storage
Store at controlled room temperature (20-25°C or 68-77°F). Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely. Chronic overdose may lead to symptoms of Cushing's syndrome, hyperglycemia, and other manifestations of hypercorticism. Treatment is symptomatic and supportive; gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, depending on manufacturer and specific formulation.
Availability
Available in pharmacies
Approval Status
FDA approved
Patent Status
Patent expired, generics available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desoximetasone for various corticosteroid-responsive dermatoses. Studies confirm its potent anti-inflammatory effects.
Lab Monitoring
- Generally not required for short-term topical use. If extensive or prolonged use, periodic evaluation for HPA axis suppression (e.g., ACTH stimulation test) may be considered, especially in children.
Doctor Notes
- Prescribe for the shortest duration possible to achieve desired clinical effect.
- Advise patients on proper application technique and warning signs of local/systemic side effects.
- Avoid use in children for extended periods without close monitoring.
Patient Guidelines
- Apply only to affected areas as directed by your doctor.
- Do not cover the treated area with bandages or other occlusive dressings unless instructed by a doctor.
- Avoid contact with eyes, nose, mouth, and groin area.
- Do not use for longer than prescribed, especially on the face or in skin folds.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra medicine to make up for a missed dose.
Driving Precautions
Topicort is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid known irritants or allergens that may worsen skin conditions.
- Keep the skin moisturized with non-medicated moisturizers if experiencing dryness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Topicort Brand
Other medicines available under the same brand name
