Topsil
Generic Name
Clemastine Fumarate
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| topsil 4 mg syrup | ৳ 30.00 | N/A |
Description
Overview of the medicine
Topsil 4 mg syrup contains Clemastine Fumarate, a first-generation antihistamine used to relieve symptoms of various allergic conditions such as allergic rhinitis, urticaria, and pruritus. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Uses & Indications
Dosage
Adults
10 mL (4 mg) orally, 2-3 times daily, or as directed by physician. Do not exceed 30 mL (12 mg) in 24 hours.
Elderly
Similar to adult dose, but use with caution due to increased susceptibility to anticholinergic effects and sedation.
Renal_impairment
No specific dosage adjustment is generally required, but use with caution.
Children_2_6_years
2.5 mL (1 mg) orally, 2 times daily, or as directed by physician. Do not exceed 7.5 mL (3 mg) in 24 hours.
Children_6_12_years
5 mL (2 mg) orally, 2 times daily, or as directed by physician. Do not exceed 15 mL (6 mg) in 24 hours.
How to Take
Take orally with or without food. Use a measuring spoon or cup to ensure accurate dosing.
Mechanism of Action
Clemastine Fumarate is a selective H1-receptor antagonist. It competitively blocks histamine from binding to H1 receptors, thereby reducing histamine-mediated effects like vasodilation, increased capillary permeability, itching, sneezing, and bronchoconstriction.
Pharmacokinetics
Onset
Antihistaminic effects typically begin within 15-30 minutes.
Excretion
Primarily excreted in the urine as metabolites; a small amount is excreted unchanged.
Half life
Plasma elimination half-life ranges from approximately 10 to 24 hours.
Absorption
Well absorbed orally. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Clemastine or any component of the formulation.
- •Newborns or premature infants.
- •Nursing mothers.
- •Patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction.
- •Concurrent use with monoamine oxidase inhibitors (MAOIs).
Drug Interactions
Anticholinergic Drugs
May have additive anticholinergic effects.
Monoamine Oxidase Inhibitors (MAOIs)
May prolong and intensify the anticholinergic effects of clemastine. Avoid concurrent use.
CNS Depressants (e.g., alcohol, sedatives, hypnotics)
Concurrent use may enhance the sedative effects of clemastine.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, severe sedation, CNS depression (leading to coma), or paradoxical CNS stimulation (especially in children) with excitement, hallucinations, convulsions, and respiratory depression. Management is supportive, including gastric lavage, activated charcoal, and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category B (some sources C). Use only if clearly needed and the benefit outweighs the potential risk to the fetus. Not recommended for use in breastfeeding mothers as it may cause sedation in the infant and decrease milk supply. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (Generic)
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Global Brand Names
International brand names for this medicine
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