Topup
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| topup 10 mg tablet | ৳ 35.00 | ৳ 140.00 |
Description
Overview of the medicine
Topup 10 mg Tablet contains Cholecalciferol (Vitamin D3), a fat-soluble vitamin essential for calcium and phosphate absorption, bone health, and immune function. This high-dose formulation is typically used to treat severe vitamin D deficiency.
Uses & Indications
Dosage
Adults
For severe deficiency, 10 mg (400,000 IU) once every 3-4 months, or as directed by physician, usually followed by lower maintenance doses. Individual dosing varies.
Elderly
Same as adults, but monitoring for renal function and calcium levels may be more frequent.
Renal_impairment
Use with caution and monitor calcium and phosphate levels; dose adjustment may be necessary. Active vitamin D metabolites (calcitriol) may be preferred in severe renal impairment.
How to Take
Oral, swallow whole with water. Can be taken with food for better absorption.
Mechanism of Action
Cholecalciferol is metabolized in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form of vitamin D. Calcitriol acts as a hormone to regulate calcium and phosphate levels by promoting absorption from the gut, reabsorption in the kidneys, and mobilization from bone.
Pharmacokinetics
Onset
Therapeutic effects may take weeks to months to become fully apparent as stores are replenished.
Excretion
Mainly excreted in the bile and feces, with a small amount in urine.
Half life
Circulating half-life of 25-hydroxyvitamin D is about 2-3 weeks; active form 1,25-dihydroxyvitamin D has a half-life of 4-6 hours.
Absorption
Readily absorbed from the gastrointestinal tract in the presence of bile salts.
Metabolism
Primarily hepatic hydroxylation to 25-hydroxyvitamin D, followed by renal hydroxylation to 1,25-dihydroxyvitamin D (calcitriol).
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any components
- Hypercalcemia or hypervitaminosis D
- Severe renal impairment (without proper monitoring)
Drug Interactions
Digoxin
Increased risk of cardiac arrhythmias if hypercalcemia occurs.
Corticosteroids
May reduce vitamin D effects.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate vitamin D metabolism, reducing its effects.
Cholestyramine, Colestipol, Orlistat
May impair absorption of vitamin D.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria), kidney damage, and cardiovascular issues. Treatment involves stopping vitamin D, hydration, and managing hypercalcemia.
Pregnancy & Lactation
Generally considered safe in recommended doses during pregnancy and lactation. High doses should be used with caution and under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to Cholecalciferol or any components
- Hypercalcemia or hypervitaminosis D
- Severe renal impairment (without proper monitoring)
Drug Interactions
Digoxin
Increased risk of cardiac arrhythmias if hypercalcemia occurs.
Corticosteroids
May reduce vitamin D effects.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin, Barbiturates
May accelerate vitamin D metabolism, reducing its effects.
Cholestyramine, Colestipol, Orlistat
May impair absorption of vitamin D.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria), kidney damage, and cardiovascular issues. Treatment involves stopping vitamin D, hydration, and managing hypercalcemia.
Pregnancy & Lactation
Generally considered safe in recommended doses during pregnancy and lactation. High doses should be used with caution and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved for vitamin D deficiency
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Extensive clinical data support the efficacy and safety of cholecalciferol in treating vitamin D deficiency and related conditions across various populations.
Lab Monitoring
- Serum 25-hydroxyvitamin D levels
- Serum calcium levels
- Serum phosphate levels
- Renal function (creatinine, eGFR)
Doctor Notes
- Advise patients on dietary calcium intake and sensible sun exposure.
- Educate on symptoms of hypercalcemia (e.g., nausea, vomiting, polyuria) and when to seek medical attention.
- Emphasize strict adherence to prescribed dosing regimen, especially for high doses, to prevent toxicity.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Generally no impairment; however, if experiencing side effects like dizziness or severe weakness, avoid driving.
Lifestyle Advice
- Maintain a balanced diet rich in calcium.
- Regular sun exposure can help vitamin D synthesis.
- Engage in weight-bearing exercises for bone health.
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