Tranexil
Generic Name
Tranexamic Acid
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| tranexil 500 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Tranexamic acid is an antifibrinolytic agent that is used to prevent and treat excessive blood loss in various medical conditions, including heavy menstrual bleeding, surgical procedures, and certain bleeding disorders.
Uses & Indications
Dosage
Adults
For menorrhagia: 1g (2 capsules) three times daily for up to 4 days. For other indications: 500 mg to 1.5 g (1-3 capsules) 2-3 times daily, depending on severity and condition.
Elderly
No specific dose reduction required unless there is renal impairment. Adjust dosage based on renal function.
Renal_impairment
Dosage reduction is necessary. For mild impairment: 500 mg twice daily. For moderate: 500 mg daily. For severe: 500 mg every 48 hours.
How to Take
Take orally, with or without food. Swallow the capsule whole with water.
Mechanism of Action
Tranexamic acid inhibits fibrinolysis by reversibly binding to plasminogen, thereby preventing its activation to plasmin. This stabilizes fibrin clots, leading to reduced bleeding.
Pharmacokinetics
Onset
Onset of action varies depending on the indication; typically within 1-2 hours for oral capsules.
Excretion
Excreted primarily unchanged in the urine via glomerular filtration.
Half life
Approximately 2 to 11 hours, significantly prolonged in renal impairment.
Absorption
Rapidly absorbed from the GI tract; bioavailability is approximately 30-50% after oral administration.
Metabolism
Minimally metabolized; less than 5% of the dose is metabolized.
Side Effects
Contraindications
- •Active intravascular clotting
- •Subarachnoid hemorrhage (due to risk of cerebral edema and infarction)
- •Severe renal impairment (risk of accumulation)
- •Hypersensitivity to tranexamic acid or any component of the formulation
- •History of convulsions
Drug Interactions
Tretinoin (oral)
Increased risk of thrombotic events when co-administered.
Estrogen/progestin containing contraceptives
Increased risk of thrombosis.
Thrombolytic agents (e.g., streptokinase, urokinase)
May antagonize the fibrinolytic effect.
Factor IX complex concentrates, Anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, hypotension, and thrombotic events. Management is symptomatic and supportive, including forced diuresis.
Pregnancy & Lactation
Pregnancy Category B (oral). Use only if clearly needed and the potential benefits outweigh the potential risks. Excreted in breast milk in very small amounts; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date (check individual product packaging)
Availability
Pharmacies, Hospitals
Approval Status
Approved (Generic)
Patent Status
Generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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